Nokea
Which of the following concepts is considered when generic drugs are substituted for brand-name drugs?
- A. Bioavailability
- B. Critical concentration
- C. Distribution
- D. Half-life
Correct Answer: A
Rationale: Bioavailability is the portion of a dose of a drug that reaches the systemic circulation and is available to act on body cells. Binders used in a generic drug may not be the same as those used in the brand-name drug. Therefore, the way the body breaks down and absorbs the drug may differ, affecting its bioavailability.
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Many patients with hyperlipidemia are treated with more than one drug. Combining a fibric acid derivative such as gemfibrozil with which of the following is not recommended? The drug and the reason must both be correct for the answer to be correct.
- A. Reductase inhibitors, due to an increased risk for rhabdomyolysis
- B. Bile-acid sequestering resins, due to interference with folic acid absorption
- C. Grapefruit juice, due to interference with metabolism
- D. Niacin, due to decreased gemfibrozil activity
Correct Answer: A
Rationale: Gemfibrozil with statins increases rhabdomyolysis risk.
The following drug may be used in the management of acromegaly:
- A. Leuprolide
- B. Octreotide
- C. Cosyntropin
- D. Desmopressin
Correct Answer: B
Rationale: Octreotide, a somatostatin analog, inhibits growth hormone in acromegaly.
What is the most likely mechanism for hip fracture in patients with glucocorticoid longterm treatment?
- A. Increased intestinal calcium absorption
- B. Increased sex hormone synthesis
- C. Inhibition of bone formation
- D. Osteoarthritis
Correct Answer: C
Rationale: Glucocorticoids inhibit bone formation by suppressing osteoblast activity, increasing osteoporosis and fracture risk.
The student nurses are learning to weigh patients and do vital signs. Weighing a client is a nursing intervention that is most important for what?
- A. Dosage calculation
- B. Assessing changes in fluid balance
- C. Assessing changes in nutritional status
- D. Caloric needs
Correct Answer: B
Rationale: Weighing assesses fluid balance changes, vital for adjusting drugs like diuretics in conditions such as CHF.
The nurse, assisting with Phase I drug studies, is talking with a woman who asks, Why can't I participate in this study? What would be the nurse's best response?
- A. Drugs pose a greater risk to women of reproductive age.
- B. Drugs are only tested on men because they are stronger.
- C. Women are more prone to adverse effects from medications.
- D. Drugs affect women differently than they affect women.
Correct Answer: A
Rationale: Phase I drug trials usually involve healthy male volunteers because chemicals may exert an unknown and harmful effect on ova in women which could result in fetal damage when the woman becomes pregnant. Drugs are tested on both men and women, but women must be fully informed of risks and sign a consent stating they understand the potential for birth defects. Women are not more prone to adverse effects of medications. Although some drugs may affect women differently than men, this is a rationale for why drugs need to be tested on women, not an explanation of why women are not included in a phase I study.