Nokea
Which of the following is a representative of sulfonylurea?
- A. Merformin
- B. Glibenclamide
- C. Acarbose
- D. Liraglutide
Correct Answer: B
Rationale: Glibenclamide is a sulfonylurea that stimulates insulin release from beta cells.
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Up to 21% of Asians are ultra-rapid 2D6 metabolizers, requiring:
- A. A need to monitor drugs metabolized by 2D6 for toxicity
- B. Increased dosages needed of drugs metabolized by 2D6, such as the selective serotonin reuptake inhibitors
- C. Decreased conversion of codeine to morphine by CYP 2D6
- D. The need for lowered dosages of drugs, such as beta blockers
Correct Answer: B
Rationale: Ultra-rapid 2D6 metabolizers (e.g., in Asians) need higher SSRI doses due to fast metabolism, unlike toxicity , codeine issues , or lower doses .
Which of the following drugs used for gout decreases net renal tubular reabsorption of uric acid?
- A. Hypoxanthine
- B. Indomethacin
- C. Colchicine
- D. Allopurinol
Correct Answer: C
Rationale: Colchicine reduces inflammation but also decreases uric acid reabsorption indirectly.
A nurse is calculating a child's medication dose by using Clark's Rule. Which of the following calculations represents the application of Clark's Rule?
- A. Infant's age in months/150 months the average adult dose
- B. Child's age in years/child's age in years +12 times the average adult dose
- C. Weight of child in pounds/150 pounds the average adult dose
- D. Surface area in square meters/1.73 the average adult dose
Correct Answer: C
Rationale: Clark's Rule uses the child's weight to calculate the dose and assumes the adult dose is based on a 150-pound person. Fried's Rule applies to a child younger than 1 year of age and assumes that an adult dose would be appropriate for a child who is 12.5 years (150 months) old. Young's Rule applies to children 1 to 12 years of age. Surface area calculation of a child's dose is determined with the use of a nomogram including the child's height and weight.
Adherence to beta blocker therapy may be affected by their:
- A. Short half-lives requiring twice daily dosing
- B. Tendency to elevate lipid levels
- C. Effects on the male genitalia, which may produce impotence
- D. None of the above
Correct Answer: C
Rationale: Impotence is a known side effect that can reduce adherence to beta blockers.
What would be the best source of drug information for a nurse?
- A. Drug Facts and Comparisons
- B. A nurse's drug guide
- C. A drug package insert
- D. The Physicians Drug Reference (PDR)
Correct Answer: B
Rationale: A nurse's drug guide provides nursing implications and patient teaching points that are most useful to nurses in addition to need-to-know drug information in a very user friendly organizational style. Lippincott's Nursing Drug Guide (LNDG) has drug monographs organized alphabetically and includes nursing implications and patient teaching points. Numerous other drug handbooks are also on the market and readily available for nurses to use. Although other drug reference books such as Drug Facts and Comparisons, PDR, and drug package inserts can all provide essential drug information, they will not contain nursing implications and teaching points and can be more difficult to use than nurse's drug guides.