Nokea
Which of the following is a stimulative mechanism of insulin secretion:
- A. Hyperglicemia and decrease of intracellular ATP
- B. Increase of intracellular ATP and opening of ATP-depended K+ channels
- C. Increase of intracellular ATP and closure of ATP-depended K+ channels
- D. Closure of potential depended Ca+2 channels
Correct Answer: C
Rationale: Insulin secretion is stimulated by increased ATP closing K+ channels, depolarizing beta cells and opening Ca2+ channels.
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Tick the substance which changes the activity of an effector element but doesn't belong to second messengers:
- A. cAMP
- B. cGMP
- C. G-protein
- D. Calcium ions
Correct Answer: C
Rationale: G-protein is a transducer, not a second messenger, unlike cAMP, cGMP, and calcium.
Besides osteoporosis, IV bisphosphonates are also indicated for:
- A. Paget's Disease
- B. Early osteopenia
- C. Renal cancer
- D. Early closure of cranial sutures
Correct Answer: A
Rationale: IV bisphosphonates treat Paget's disease by reducing bone turnover; osteopenia uses oral forms typically.
When assessing a patient prior to starting a drug regimen it is often necessary to have a baseline kidney function study done. What might kidney impairment indicate in relation to drug therapy?
- A. Pharmacodynamics stable at the therapeutic dose
- B. Contraindication to the use of a drug
- C. Increased dosage of a drug
- D. Decreased adverse effects of a drug
Correct Answer: B
Rationale: Kidney impairment may contraindicate certain drugs due to reduced clearance, risking toxicity.
Which drug(s) would be considered to be in the category Schedule II? (Select all that apply.)
- A. Marijuana
- B. Morphine
- C. Amphetamines
- D. Fiorinal
Correct Answer: C
Rationale: Percodan and amphetamines are Schedule II drugs with high abuse potential. Marijuana is Schedule I, Fiorinal is Schedule III.
While taking an angiotensin II receptor blocker (ARB), patients need to avoid certain over-the-counter drugs without first consulting the provider because:
- A. Cimetidine is metabolized by the CYP 3A4 isoenzymes
- B. Nonsteroidal anti-inflammatory drugs reduce prostaglandin levels
- C. Both 1 and 2
- D. Neither 1 nor 2
Correct Answer: B
Rationale: NSAIDs reduce prostaglandins, counteracting ARB's renal protective effects.