Nokea
Which of the following is an example of humanized anti-human IL-6 receptor monoclonal antibody?
- A. Infliximab
- B. Adalimumab
- C. Tocilizumab
- D. Anakinra
Correct Answer: C
Rationale: Tocilizumab is a humanized monoclonal antibody that targets the IL-6 receptor, used in treating inflammatory conditions.
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The following statements concerning acute gastroenteritis in childhood are correct:
- A. Intravenous fluid therapy is essential in severe cases
- B. Loperamide should be avoided
- C. The commonest causes of failure to thrive following an attack is persistent bacterial infection
- D. Septicaemia is a recognised feature of Salmonella gastroenteritis
Correct Answer: A
Rationale: Intravenous fluid therapy is critical in severe dehydration due to gastroenteritis. Loperamide is contraindicated in children due to risk of serious side effects. Persistent bacterial infection is not the commonest cause of failure to thrive, and septicaemia is rare in Salmonella gastroenteritis.
Duchenne muscular dystrophy (DMD):
- A. Affects dystrophin gene
- B. Features usually present before five years of age
- C. Frontal baldness occurs
- D. Is part of the differential diagnosis in a floppy infant
Correct Answer: B
Rationale: Features usually present before five years of age
Regarding a supracristal VSD, the following are true EXCEPT
- A. incidence is higher in Asian children
- B. complicated by aortic insufficiency in 50-90% of patients
- C. aortic insufficiency is most often not recognized until late in the lst decade of life
- D. murmur of a supracristal VSD is usually heard at the mid to upper left sternal border
Correct Answer: D
Rationale: Closure of asymptomatic supracristal VSDs at the time of diagnosis is not recommended.
Which plan would be appropriate in helping to control congestive heart failure (CHF) in an infant?
- A. Promoting fluid restriction
- B. Feeding a low-salt formula
- C. Feeding in semi-Fowler position
- D. Encouraging breast milk
Correct Answer: C
Rationale: Feeding in a more upright position helps fluid drain from the lungs, improving breathing and reducing cardiac workload.
Common causes of seizures in a neonate are:
- A. Hypocalcaemia
- B. Hypoglycaemia
- C. Pyridoxine deficiency
- D. Hydrocephalus
Correct Answer: B
Rationale: The correct answer is B because hypoglycaemia is a common cause of neonatal seizures. The other options (a, c, d, e) are also causes but less common.