Nokea
Which of the following is NOT a common condition associated with Type I hypersensitivity?
- A. Asthma
- B. Food allergies
- C. Anaphylaxis
- D. Systemic lupus erythematosus (SLE)
Correct Answer: D
Rationale: The correct answer is D: Systemic lupus erythematosus (SLE). Type I hypersensitivity involves IgE-mediated reactions to allergens, leading to immediate responses like asthma, food allergies, and anaphylaxis. SLE is an autoimmune disease involving immune complexes and not IgE antibodies. Therefore, SLE is not directly associated with Type I hypersensitivity. Asthma, food allergies, and anaphylaxis are all examples of Type I hypersensitivity reactions due to IgE-mediated mechanisms.
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What is a significant consequence of the evolutionary arms race between hosts and pathogens?
- A. Pathogens evolve slower than hosts
- B. Hosts develop epigenetic changes for immune adaptation
- C. Mutations in hosts always outpace pathogen evolution
- D. Hosts and pathogens remain static in their interactions
Correct Answer: B
Rationale: The correct answer is B because hosts developing epigenetic changes for immune adaptation is a significant consequence of the evolutionary arms race between hosts and pathogens. This adaptation allows hosts to better defend against evolving pathogens over time. This process is dynamic, as both hosts and pathogens continuously evolve in response to each other.
Choice A is incorrect because pathogens can evolve rapidly to adapt to host defenses. Choice C is incorrect because while hosts may have mutations that provide advantages, pathogens can also evolve to overcome host defenses. Choice D is incorrect as the interaction between hosts and pathogens is characterized by constant adaptation and change, not remaining static.
What is included in the humoral immune response?
- A. Surveillance for malignant cell changes
- B. Production of antigen-specific immunoglobulins
- C. Direct attack of antigens by activated B lymphocytes
- D. Releasing cytokines responsible for destruction of antigens
Correct Answer: B
Rationale: The humoral immune response involves the production of antigen-specific antibodies (immunoglobulins) by B cells, which neutralize pathogens.
Which classification of chemotherapy drugs is cell cycle phase–nonspecific, breaks the DNA helix which interferes with DNA replication, and crosses the blood-brain barrier?
- A. Nitrosureas
- B. Antimetabolites
- C. Mitotic inhibitors
- D. Antitumor antibiotics
Correct Answer: A
Rationale: Nitrosureas are cell cycle phase–nonspecific, disrupt DNA replication, and cross the blood-brain barrier.
Attenuated vaccines can be obtained by
- A. Passage through cultured cells
- B. Formaldehyde treatment
- C. The use of viral vectors carrying pathogen subunits
- D. All of the above treatments would lead to attenuated vaccines
Correct Answer: A
Rationale: The correct answer is A: Passage through cultured cells. Attenuated vaccines are produced by weakening the pathogen through serial passages in cultured cells, reducing virulence while maintaining immunogenicity. Formaldehyde treatment (B) disrupts the pathogen's structure and is used for inactivated vaccines. The use of viral vectors carrying pathogen subunits (C) is a method for creating subunit vaccines, not attenuated vaccines. Therefore, D is incorrect as not all treatments lead to attenuated vaccines.
Benefits from the human microbiome include all the following except:
- A. Out-competition of pathogenic species
- B. Production of important metabolites called short chain fatty acids
- C. Secretion of enzymes such as lysozyme that degrade the cell wall of pathogenic species
- D. Provision of signals leading to the development of the gut-associated immune system
Correct Answer: C
Rationale: The correct answer is C because the human microbiome does not secrete enzymes like lysozyme; instead, lysozyme is produced by the human body. A is correct as the microbiome can out-compete harmful bacteria. B is correct as the microbiome produces short chain fatty acids. D is correct as the microbiome helps in the development of the gut-associated immune system. Therefore, C is the only option that does not accurately describe a benefit from the human microbiome.