Which of the following is not a side effect of loop diuretics?
- A. Alkalosis
- B. Nausea
- C. Hypotension
- D. Potassium deficits
Correct Answer: B
Rationale: The correct answer is B: Nausea. Loop diuretics like furosemide work by inhibiting the reabsorption of sodium and water in the loop of Henle in the kidneys. This mechanism can lead to electrolyte imbalances, such as potassium deficits (choice D), and volume depletion, resulting in hypotension (choice C). Loop diuretics can also cause metabolic alkalosis (choice A) due to loss of hydrogen ions. Nausea, however, is not a common side effect of loop diuretics. Therefore, choice B is not a side effect of loop diuretics, making it the correct answer.
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Which of the following conditions is not treated with Prednisone?
- A. Cushing's disease
- B. Testicular cancer
- C. Lymphomas
- D. Chronic leukemias
Correct Answer: B
Rationale: Prednisone is a corticosteroid used to treat inflammatory conditions and certain types of cancer. Testicular cancer is not typically treated with Prednisone because it is a form of cancer that requires specific treatments such as surgery, chemotherapy, or radiation therapy. Prednisone is not the primary treatment option for testicular cancer. In contrast, Prednisone is commonly used to manage symptoms in conditions like Cushing's disease, lymphomas, and chronic leukemias by reducing inflammation and suppressing immune response. Therefore, choice B is the correct answer as Prednisone is not a standard treatment for testicular cancer.
Which of the following drugs is associated with hepatitis as a reaction?
- A. Valproic acid
- B. Quinidine
- C. Isoniazid
- D. Ethosuximide
Correct Answer: C
Rationale: Correct Answer: C (Isoniazid)
Rationale:
1. Isoniazid is known to cause drug-induced hepatitis due to its hepatotoxic effects.
2. It can lead to liver inflammation, causing hepatitis as a reaction.
3. Regular monitoring of liver function tests is essential when using isoniazid.
Summary of other choices:
A. Valproic acid: Can cause hepatotoxicity but not specifically linked to hepatitis.
B. Quinidine: Mainly known for cardiac side effects, not commonly associated with hepatitis.
D. Ethosuximide: Primarily used for treating absence seizures, not typically associated with hepatitis.
Which of the following is not a side effect associated with Prednisone toxicity?
- A. Cataracts
- B. Hypotension
- C. Psychosis
- D. Acne
Correct Answer: B
Rationale: The correct answer is B: Hypotension. Prednisone toxicity typically causes hypertension, not hypotension. Prednisone can lead to increased blood pressure due to its sodium-retaining effects. Cataracts (A), Psychosis (C), and Acne (D) are all known side effects of Prednisone toxicity. Cataracts can form due to long-term steroid use, psychosis can occur especially at higher doses, and acne is a common skin side effect. Therefore, hypotension is the odd one out among the choices given.
Which of the following drugs is associated with Stevens-Johnson syndrome?
- A. Valproic acid
- B. Quinidine
- C. Isoniazid
- D. Ethosuximide
Correct Answer: D
Rationale: Step 1: Ethosuximide is the correct answer as it is a known trigger for Stevens-Johnson syndrome due to its association with hypersensitivity reactions.
Step 2: Valproic acid can cause liver toxicity but is not typically linked to Stevens-Johnson syndrome.
Step 3: Quinidine is associated with drug-induced lupus but not commonly known to cause Stevens-Johnson syndrome.
Step 4: Isoniazid is linked to drug-induced hepatitis but not typically associated with Stevens-Johnson syndrome.
In summary, Ethosuximide is the correct choice due to its well-documented association with Stevens-Johnson syndrome, while the other options are linked to different adverse effects.
Which of the following conditions are not treated with opioid analgesics like dextromethorphan and methadone?
- A. Pulmonary Edema
- B. Cough suppression
- C. Sedation
- D. Pain
Correct Answer: C
Rationale: The correct answer is C: Sedation. Opioid analgesics like dextromethorphan and methadone are primarily used for pain management, not sedation. They work by binding to opioid receptors in the brain to reduce pain perception. Pulmonary edema can be managed with diuretics, cough suppression with antitussives, and sedation with sedatives/hypnotics. Therefore, sedation is not a condition typically treated with opioid analgesics.