Nokea
Which of the following is used for treatment of hyperthyroidism:
- A. Liothironine
- B. Levothiroxine
- C. Propilthiouracil
- D. Liotrix
Correct Answer: C
Rationale: Propylthiouracil inhibits thyroid hormone synthesis, making it a standard treatment for hyperthyroidism.
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Which of the following stimulated production of thyroid hormones:
- A. Thyrotropic hormone
- B. Corticosteroids
- C. Dopamine
- D. Somatostatine
Correct Answer: A
Rationale: Thyrotropic hormone (TSH) stimulates the thyroid to produce T3 and T4.
Not metabolized in liver
- A. Cimetidine
- B. Phenytoin
- C. Diazepam
- D. Penicillin G
Correct Answer: D
Rationale: Penicillin G is primarily excreted unchanged by the kidneys, unlike the others metabolized by the liver.
Vitamin B12 deficiency may lead to:
- A. Hair loss
- B. Insomnia
- C. Dry scales on the scalp
- D. Numbness and tingling of the hands
Correct Answer: D
Rationale: Vitamin B12 deficiency causes neurological symptoms like numbness and tingling due to nerve damage.
The volume of distribution (Vd) for a drug highly bound in peripheral tissues would be?
- A. High
- B. Low
- C. Unchanged
- D. Cannot be determined
Correct Answer: A
Rationale: A drug highly bound in peripheral tissues has a high Vd, as it distributes extensively beyond plasma, often exceeding total body water (e.g., >0.6 L/kg).
A nurse is caring for a client with hyperparathyroidism and notes that the client's serum calcium level is 13 mg/dL. Which medication should the nurse prepare to administer as prescribed to the client?
- A. Calcium chloride
- B. Calcium gluconate
- C. Calcitonin (Miacalcin)
- D. Large doses of vitamin D
Correct Answer: C
Rationale: The normal serum calcium level is 8.6 to 10.0 mg/dL. This client is experiencing hypercalcemia. Calcium gluconate and calcium chloride are medications used for the treatment of tetany, which occurs as a result of acute hypocalcemia. In hypercalcemia, large doses of vitamin D need to be avoided. Calcitonin, a thyroid hormone, decreases the plasma calcium level by inhibiting bone resorption and lowering the serum calcium concentration.