Nokea
Which of the following is used for treatment of mixedema:
- A. Triiodthironine
- B. Potassium perchlorate
- C. Mercazolil
Correct Answer: A
Rationale: Triiodothyronine (T3) is used to treat myxedema (severe hypothyroidism) by replacing deficient thyroid hormone.
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Which of the following is an advantage of sublingual administration?
- A. Rapid absorption
- B. Convenient
- C. Avoid harsh GI environment
- D. Avoid first pass-metabolism
Correct Answer: D
Rationale: Sublingual administration offers rapid absorption , convenience , avoids the GI tract , and bypasses first-pass metabolism ; all are true, but D is a key pharmacological advantage.
Antacids such as calcium carbonate (Tums) can reduce the absorption of which of the following nutrients?
- A. Protein
- B. Calcium
- C. Iron
- D. Vitamin K
Correct Answer: C
Rationale: Calcium carbonate binds to iron, forming insoluble complexes that reduce iron absorption.
Because of their site of action, bile acid sequestering resins:
- A. Should be administered separately from other drugs by at least 4 hours
- B. May increase the risk for bleeding
- C. Both 1 and 2
- D. Neither 1 nor 2
Correct Answer: A
Rationale: Bile acid resins bind drugs in the gut, requiring separation by 4 hours.
Which of the following legislative acts allowed the Food and Drug Administration (FDA) to tighten control over the quality of drugs and required that safety and efficacy standards be established?
- A. Pure Food and Drug Act of 1906
- B. Federal Food, Drug, and Cosmetic Act of 1938
- C. Durham Humphrey Amendment of 1951
- D. Kefauver-Harris Act of 1962
Correct Answer: D
Rationale: The Kefauver-Harris Act was the result of the use of the 1960s drug thalidomide (Thalomid). The public concern led to the legislation that gave the FDA regulatory control over testing and evaluating of drugs and allowed it to set standards for efficacy and safety. The Pure Food and Drug Act required labeling to eliminate false claims. The Federal Food, Drug, and Cosmetic Act gave the FDA the power to enforce standards for testing drug toxicity and monitoring labeling. The Durham-Humphrey Amendment enforced prescriptions for distribution.
Patients who are being treated with epoetin alfa need to be monitored for the development of:
- A. Thrombocytopenia
- B. Neutropenia
- C. Hypertension
- D. Gout
Correct Answer: C
Rationale: Epoetin alfa can cause hypertension by increasing red cell mass; blood count issues or gout are less common.