Nokea
A provider may consider testing for CYP2D6 variants prior to starting tamoxifen for breast cancer to:
- A. Ensure the patient will not have increased adverse effects from the tamoxifen
- B. Identify if the patient is a poor metabolizer, potentially reducing conversion to active metabolites
- C. Evaluate risk of drug interactions with tamoxifen
- D. Determine if the patient requires a higher dose due to ultra-rapid metabolism
Correct Answer: B
Rationale: CYP2D6 testing identifies poor metabolizers who may not convert tamoxifen to its active form (endoxifen), impacting efficacy, not just ADRs or interactions .
You may also like to solve these questions
Which of the following is a luminal amebecide drug?
- A. Metronidazole
- B. Emtine
- C. Doxycycline
- D. Dicloxinide
Correct Answer: D
Rationale: Diloxanide (likely misspelled as Dicloxinide) is a luminal amebicide used to eradicate cysts of Entamoeba histolytica in the intestinal lumen, unlike metronidazole, which targets systemic infection.
The direct costs of drug therapy include:
- A. The actual cost of acquiring the medication
- B. The loss of income due to illness
- C. Pain and suffering due to inadequate drug therapy
- D. The cost of a funeral associated with premature death
Correct Answer: A
Rationale: Direct costs are the tangible expenses of acquiring the drug itself.
Because of their site of action, bile acid sequestering resins:
- A. Should be administered separately from other drugs by at least 4 hours
- B. May increase the risk for bleeding
- C. Both 1 and 2
- D. Neither 1 nor 2
Correct Answer: A
Rationale: Bile acid resins bind drugs in the gut, requiring separation by 4 hours.
The nursing assessment identifies that the client is nauseated and cannot take acetaminophen (Tylenol) orally. Which is true regarding the substitution of this medication to suppository form?
- A. It is standard practice when the patient is unable to take the ordered medication.
- B. It is acceptable if the patient agrees to the altered route form.
- C. It is preferable to having the patient miss a dose of the medication.
- D. It is contraindicated without an order from the health care provider.
Correct Answer: D
Rationale: One dosage form of medication should never be substituted for another unless the prescriber is consulted; there can be a great variation in the absorption rate of the medication through different routes of administration. The substitution of one form for another is not standard practice, and is not acceptable or preferable without the prescriber's order.
Behaviors predictive of addiction to controlled substances include:
- A. Stealing or borrowing another patient's drugs
- B. Requiring increasing doses of opiates for pain associated with malignancy
- C. Receiving refills of a Schedule II prescription on a regular basis
- D. Requesting that only their own primary care provider prescribe for them
Correct Answer: A
Rationale: Stealing/borrowing drugs strongly predicts addiction, unlike cancer-related dose increases or regular refills/provider preference , which may be legitimate.