Nokea
Which of the following statement is correct for Amantadine?
- A. Has agonistic action on NDMA type of glutamate receptors
- B. It was developed as antiepileptic drug
- C. Acts as a D2 blocker
- D. Produces livedo reticularis as side effect
Correct Answer: D
Rationale: Amantadine, an antiviral and antiparkinsonian drug, can cause livedo reticularis (a skin mottling side effect); it blocks NMDA receptors, not agonizes them, and enhances dopamine release, not blocks D2.
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True contraindications to diphtheria, tetanus, and acellular pertussis (DTaP or Tdap) vaccine include:
- A. Fever up to 104°F (40.5°C) after previous DTaP vaccine
- B. Family history of seizures after DTaP vaccine
- C. Adolescent pregnancy
- D. Anaphylactic reaction with a previous dose
Correct Answer: D
Rationale: Anaphylaxis is a true contraindication to DTaP/Tdap; fever , family history , or pregnancy are not.
In an acute attack of migraine, the drug of choice is
- A. Ergotamine tartrate
- B. Methysergide
- C. Propranolol
- D. Caffeine
Correct Answer: A
Rationale: Ergotamine tartrate is the drug of choice for acute migraine.
You are assigned to infuse 300 mL of a solution over 2 hours with a drop factor of 15 gtt/mL. What is the flow rate in drops per minute?
- A. 25 gtt/min
- B. 37.5 gtt/min
- C. 45 gtt/min
- D. 75 gtt/min
Correct Answer: B
Rationale: Flow rate = (300 mL 15 gtt/mL) ÷ (2 60) = 4,500 ÷ 120 = 37.5 gtt/min, exactly matching option B.
Identify potential drug-drug interactions that may occur with tamoxifen
- A. Not provided in document
- B. Not provided in document
- C. Not provided in document
- D. Not provided in document
Correct Answer: D
Rationale: This question lacks options in the document, but based on the answer key (ANS: 4), it is assumed to correspond to the fourth choice if options were present. Tamoxifen has significant interactions with CYP2D6 inhibitors (e.g., SSRIs), which can reduce its efficacy.
45 year old female has a diabetes mellitus. Endocrinologist prescribes treatment, which has a side effect as hypoglycemia and weight gain. Which of the following drug is prescribed?
- A. Canagliflozin
- B. Exenatide
- C. Gliburide
- D. Pramlintide
Correct Answer: C
Rationale: Gliburide, a sulfonylurea, commonly causes hypoglycemia and weight gain due to increased insulin release.