Nokea
Which of the following statements about Thalidomide is INCORRECT?
- A. It is anti angiogenic
- B. It is anti inflammatory
- C. It is immunomodulatory
- D. It is mitogenic
Correct Answer: D
Rationale: Thalidomide is not mitogenic; it inhibits cell proliferation.
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Ginseng, which is taken to assist with memory, may potentiate:
- A. Aricept
- B. Insulin
- C. Digoxin
- D. Propranolol
Correct Answer: C
Rationale: Ginseng can increase digoxin levels, potentially leading to toxicity.
Which statement is false of Domperidone
- A. Chemically related to haloperidol
- B. Pharmacologically related to metoclopramide
- C. Extra pyramidal symptoms are common
- D. It counteracts the emetic action but not the therapeutic effect in parkinsonism
Correct Answer: C
Rationale: Domperidone rarely causes extrapyramidal symptoms as it doesn't cross the blood-brain barrier.
The hypoglycemic mechanism of action of pioglitazone and rosiglitazon is:
- A. They are peroxisome proliferator activating receptor gamma (PPAR-Y) ligands and enhance absorption of glucose and fatty acid
- B. Enhance closure of ATP sensitive K+ channels and entrance of calcium in intracellular efflux via Ca2+ channels
- C. Decrease gluconeogenesis in the liver
- D. Increase tyrosine kinase activity
Correct Answer: A
Rationale: Pioglitazone and rosiglitazone activate PPAR-gamma, improving insulin sensitivity and glucose uptake in tissues.
A nurse is caring for a client who has a prescription for Bethanechol to treat urinary retention. The nurse should recognize that which of the following findings is a manifestation of muscarinic stimulation?
- A. Dry mouth
- B. Hypertension
- C. Excessive perspiration
- D. Fecal impaction
Correct Answer: C
Rationale: Bethanechol stimulates muscarinic receptors, causing excessive perspiration , not dry mouth.
Which of the following adverse effects may occur due to a dihydropyridine-type calcium channel blocker?
- A. Bradycardia
- B. Hepatic impairment
- C. Increased contractility
- D. Edema of the hands and feet
Correct Answer: D
Rationale: Dihydropyridines (e.g., amlodipine) cause peripheral edema due to vasodilation.