Nokea
Which of the following viral infections can result in chronic carrier state.
- A. HBV
- B. HCV
- C. HDV
- D. All of these
Correct Answer: D
Rationale: The correct answer is D: All of these. HBV, HCV, and HDV can all lead to chronic carrier states due to their ability to establish persistent infections in the liver. HBV can result in chronic hepatitis, cirrhosis, and even liver cancer. HCV can also lead to chronic hepatitis and liver damage. HDV is a defective virus that requires HBV for replication and can worsen the outcome of HBV infection, potentially leading to chronic liver disease. Therefore, all three viruses have the potential to cause chronic carrier states.
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The catarrhal stage of the whooping cough is characterized by:
- A. Decrease in paroxysms of coughing
- B. Subsequent respiratory infection for many months after the onset of pertussis
- C. Uncontrollable coughing followed by a high pitched 'whoop' sound
- D. Mild respiratory symptoms (mild coughing, sneezing or a runny nose)
Correct Answer: D
Rationale: The correct answer is D because the catarrhal stage of whooping cough is characterized by mild respiratory symptoms such as mild coughing, sneezing, or a runny nose. During this stage, the cough may start to worsen but is not yet severe.
A: Incorrect - Decrease in paroxysms of coughing is not seen in the catarrhal stage; it occurs later in the paroxysmal stage.
B: Incorrect - Subsequent respiratory infection for many months after the onset of pertussis is not a characteristic of the catarrhal stage.
C: Incorrect - Uncontrollable coughing followed by a high pitched 'whoop' sound is typical of the paroxysmal stage, not the catarrhal stage.
Enriched growth media:
- A. Belong to the minimal media and inhibit the development of gram+ cocci
- B. Support the development of the target bacteria groups without suppressing the growth of other microorganisms
- C. Are intended for the cultivation of only one microbial species
- D. Support the development of target bacteria groups and suppress the development of other microorganisms
Correct Answer: B
Rationale: The correct answer is B because enriched growth media provide essential nutrients that support the growth of target bacteria groups without inhibiting the growth of other microorganisms. This allows for the selective cultivation of specific microbes while still allowing for the growth of other organisms present in the sample. Choice A is incorrect because enriched media do not belong to minimal media and do not inhibit the development of gram+ cocci. Choice C is incorrect because enriched media can support the growth of multiple microbial species. Choice D is incorrect because enriched media do not suppress the development of other microorganisms but rather provide nutrients to support their growth alongside the target bacteria groups.
The term used to describe an inflammation of the saclike membrane surrounding the heart is:
- A. peritonitis
- B. pericarditis
- C. myocardial infarction
- D. anemia
Correct Answer: B
Rationale: The correct answer is B: pericarditis. Pericarditis refers to inflammation of the pericardium, the sac-like membrane surrounding the heart. This condition can cause chest pain, fever, and other symptoms related to the heart. Peritonitis (A) is inflammation of the peritoneum, not the pericardium. Myocardial infarction (C) is a heart attack caused by a blockage in the coronary arteries, not inflammation of the pericardium. Anemia (D) is a condition characterized by a deficiency of red blood cells or hemoglobin, not related to inflammation of the pericardium.
Anticodon is:
- A. Produced during the process of replication
- B. A nucleotide triplet on the molecule of mRNA
- C. A nucleotide DNA triplet defining the amino acid which has a specific sequence on the polypeptide chain during the translation
- D. A nucleotide triplet forming a unit of genetic code in a transfer RNA molecule corresponding to a complementary codon on messenger RNA
Correct Answer: D
Rationale: The correct answer is D because an anticodon is a nucleotide triplet in a tRNA molecule that pairs with a complementary codon on mRNA during translation. Step 1: Anticodons are found in tRNA, not in DNA or mRNA. Step 2: Anticodons specifically bind to codons on mRNA to ensure correct amino acid incorporation into the growing polypeptide chain, making option D the most accurate choice. Option A is incorrect as replication does not involve anticodons. Option B is incorrect because codons, not anticodons, are found on mRNA molecules. Option C is incorrect as it describes a codon on DNA, not an anticodon on tRNA.
After a prolonged isoniazid treatment, the patient developed polyneuritis, paresthesia, memory disorders, and convulsions. What is the most likely mechanism of the described isoniazid side-effects?
- A. Disruption of cell membrane synthesis
- B. Inhibition of protein synthesis
- C. Inhibition of RNA-synthesis
- D. Inhibition of pyridoxal phosphate synthesis
Correct Answer: D
Rationale: The correct answer is D. Isoniazid inhibits pyridoxal phosphate synthesis, which is the active form of vitamin B6. Pyridoxal phosphate is essential for various enzymatic reactions, including neurotransmitter synthesis and myelin formation. Therefore, isoniazid-induced pyridoxal phosphate deficiency can lead to neurological symptoms like polyneuritis, paresthesia, memory disorders, and convulsions.
A: Disruption of cell membrane synthesis - This is not the mechanism of isoniazid side-effects.
B: Inhibition of protein synthesis - Isoniazid does not directly inhibit protein synthesis.
C: Inhibition of RNA-synthesis - Isoniazid does not inhibit RNA synthesis; it affects vitamin B6 metabolism.