Anatomy of Hematologic System Related

Review Anatomy of Hematologic System related questions and content

You are seeing a 13-year-old boy with fatigue, weight loss, night sweats, and splenomegaly. Peripheral blood shows anemia, thrombocytosis, and leukocytosis (300,000/mm3). What is this patient's most likely diagnosis?

  • A. Leukemoid reaction
  • B. Acute lymphoblastic leukemia (ALL)
  • C. Chronic myeloid leukemia (CML)
  • D. Juvenile myelomonocytic leukemia (JMML)
Correct Answer: C

Rationale: The most likely diagnosis for this 13-year-old boy presenting with fatigue, weight loss, night sweats, splenomegaly, anemia, thrombocytosis, leukocytosis (300,000/mm3) is Chronic Myeloid Leukemia (CML).
1. Presence of anemia, thrombocytosis, and leukocytosis is characteristic of CML.
2. CML typically presents with splenomegaly.
3. Age of onset (13 years) is within the typical range for CML.
4. The Philadelphia chromosome (t(9;22)) is present in most cases of CML, aiding in diagnosis.
5. Leukemoid reaction (A) is a reactive increase in white blood cells, not a primary neoplastic disorder.
6. Acute lymphoblastic leukemia (ALL) (B) typically presents with bone pain, lymphadenopathy, and CNS symptoms in children.
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