Nokea
You prescribe bromocriptine for a woman with primary amenorrhea. Normal menstruation returns about a month after starting therapy. Which of the following statements best describes the mechanism by which bromocriptine caused its desired effects?
- A. Blocked estrogen receptors, enhanced gonadotropin release
- B. Increased FSH synthesis
- C. Inhibited prolactin release
- D. Stimulated ovarian estrogen and progestin synthesis
Correct Answer: C
Rationale: Bromocriptine, a dopamine agonist, inhibits prolactin, restoring ovulation in hyperprolactinemia.
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Where are tight junctions created by two adjoining cells located?
- A. Bone
- B. Brain
- C. Skin
- D. Liver
Correct Answer: B
Rationale: Tight junctions are prominent in the brain (blood-brain barrier), restricting drug entry, unlike the liver (fenestrated) or bone/skin (different barriers).
Which of the following is a carbapenem antibiotic?
- A. Meropenem
- B. Ceftriaxone
- C. Amoxicillin
- D. Aztreonam
Correct Answer: A
Rationale: Meropenem is a carbapenem, a broad-spectrum beta-lactam antibiotic, unlike ceftriaxone (cephalosporin) or amoxicillin (penicillin).
Glucocorticoids:
- A. Decrease amount of immunocompetent cells and macrophages in the blood
- B. Stimulate activity of macrophages and monocytes
- C. Increase amount of T lymphocytes
- D. Stimulate production of antibodies
Correct Answer: A
Rationale: Glucocorticoids reduce immunocompetent cells and macrophages, contributing to their immunosuppressive effects.
All are pro drugs except
- A. Sulindac
- B. Codeine
- C. Talampicillin
- D. Chlorpromazine
Correct Answer: D
Rationale: Chlorpromazine is active as is; others are prodrugs.
What is the responsibility of the nurse related to the patient's drug therapy? (Select all that apply.)
- A. Teaching the patient how to cope with therapy to ensure the best outcome
- B. Providing therapy as well as medications
- C. Changing of therapy routines
- D. Altering the drug regimen to optimize outcome
Correct Answer: A
Rationale: Nurses teach patients, evaluate therapy effectiveness, but do not alter regimens (physician's role) or provide therapy beyond medication administration.