Nokea
Which of the following best describes the effect of propylthiouracil on thyroid hormone production?
- A. It blocks the release of thyrotropin-releasing hormone
- B. It inhibits uptake of iodide by thyroid cells
- C. It prevents the release of thyroid hormone from thyroglobulin
- D. It blocks iodination and coupling of tyrosines in thyroglobulin to form thyroid hormones
Correct Answer: D
Rationale: Propylthiouracil blocks iodination and coupling in thyroglobulin, inhibiting thyroid hormone synthesis.
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First dose phenomenon is a characteristic side effect on initiation of antihypertensive therapy with
- A. Minoxidil
- B. Clonidine
- C. Metroprolol
- D. Prazosin
Correct Answer: B
Rationale: Clonidine can cause sedation or hypotension after the first dose.
T½ of a drug can determine all the following
- A. Closing interval
- B. Elimination time
- C. Steady Plasma Concentration
- D. Therapeutic dosage
Correct Answer: D
Rationale: Half-life (t½) informs dosing intervals to maintain therapeutic levels.
A nurse is caring for a client who has Depression and a new prescription for Venlafaxine. For which of the following adverse effects should the nurse monitor this client? (Select all that apply)
- A. Cough
- B. Dizziness
- C. Increased libido
- D. Invention
Correct Answer: B
Rationale: Venlafaxine can cause dizziness , decreased libido , and hypotension ; 'invention' seems a typo.
Behaviors predictive of addiction to controlled substances include:
- A. Stealing or borrowing another patient's drugs
- B. Requiring increasing doses of opiates for pain associated with malignancy
- C. Receiving refills of a Schedule II prescription on a regular basis
- D. Requesting that only their own primary care provider prescribe for them
Correct Answer: A
Rationale: Stealing/borrowing drugs strongly predicts addiction, unlike cancer-related dose increases or regular refills/provider preference , which may be legitimate.
Which drug has a high first pass effect
- A. Amiodarone
- B. Phenytoin
- C. Verapamil
- D. Disopyramide
Correct Answer: C
Rationale: Verapamil undergoes extensive first-pass metabolism in the liver, reducing its bioavailability when taken orally.