Howard is a 72-year-old male who occasionally takes diphenhydramine for his seasonal allergies. Monitoring for this patient taking diphenhydramine would include assessing for:
- A. Urinary retention
- B. Cardiac output
- C. Peripheral edema
- D. Skin rash
Correct Answer: A
Rationale: Diphenhydramine , an antihistamine, has anticholinergic effects that can cause urinary retention, especially in older males; other effects are less common.
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The following drugs can be used for treatment of diabetes except one:
- A. Insulines
- B. Biguanides
- C. alfa glucosidase inhibitors
- D. Glucagon
Correct Answer: D
Rationale: Glucagon increases blood glucose levels by promoting glycogenolysis and gluconeogenesis, making it unsuitable for diabetes treatment, unlike the others which lower glucose.
Isoproterenol produces maximal contraction of cardiac muscle in a manner similar to epinephrine. Which of the following best describe isoproterenol?
- A. Fuller agonist
- B. Partial agonist
- C. Irreversible antagonist
- D. Inverse agonist
Correct Answer: A
Rationale: Isoproterenol's maximal effect similar to epinephrine indicates it is a full agonist at beta receptors.
A patient may develop neutropenia from using topical Silvadene for burns. Neutropenia is a(n):
- A. Cytotoxic hypersensitivity reaction
- B. Immune complex hypersensitivity
- C. Immediate hypersensitivity reaction
- D. Delayed hypersensitivity reaction
Correct Answer: A
Rationale: Neutropenia from Silvadene (silver sulfadiazine) is a Type II cytotoxic reaction , targeting blood cells, not immune complex , immediate , or delayed .
Drug which interferes with metabolism of theophylline is:
- A. Erythromycin
- B. Gentamicin
- C. Penicillin
- D. Furazolidone
Correct Answer: A
Rationale: Erythromycin inhibits P-450, increasing theophylline levels.
Patients who are on chronic long-term corticosteroid therapy need education regarding:
- A. Receiving all vaccinations, especially the live flu vaccine
- B. Reporting black tarry stools or abdominal pain
- C. Eating a high carbohydrate diet with plenty of fluids
- D. Small amounts of alcohol are generally tolerated
Correct Answer: B
Rationale: Black tarry stools signal GI bleeding from corticosteroids; live vaccines are contraindicated.