Which is not an antithyroid drug?
- A. Mercazolile
- B. Triiodthyronine
- C. Diiodthyrosine
- D. Potassium iodade
Correct Answer: B
Rationale: Triiodothyronine (T3) is a thyroid hormone, not an antithyroid drug, unlike the others which inhibit thyroid function.
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Pregnant patients who are taking isoniazid (INH) should take 25 mg/day of vitamin B6 (pyridoxine) to prevent:
- A. Beriberi
- B. Peripheral neuropathy
- C. Rickets
- D. Megaloblastic anemia
Correct Answer: B
Rationale: Vitamin B6 supplementation prevents INH-induced peripheral neuropathy.
The 'donut hole' in Medicare Part D:
- A. Will be totally eliminated with the federal health-care reform enacted in 2010
- B. Refers to the period of time when annual individual drug costs are between 250 and 2,250 per year and drug costs are covered 75%
- C. Refers to the period between when the annual individual drug costs are 2,970 and 4,750 and the patient pays 52.5% of the costs of brand name drugs (2013)
- D. Has no effect on whether patients continue to fill their prescriptions during the coverage gap
Correct Answer: C
Rationale: The donut hole (2013) is the coverage gap where patients pay more out-of-pocket.
The volume of distribution (Vd) for a drug that is completely retained in the vascular compartment would be?
- A. High
- B. Low
- C. Unchanged
- D. Cannot be determined
Correct Answer: B
Rationale: A drug confined to the vascular compartment (e.g., plasma) has a low Vd, close to plasma volume (about 0.06 L/kg), indicating limited distribution.
The nurse administers amoxicillin 500 mg. The half-life of this drug is approximately 1 hour. At what point would the drug level in the body be 62.5 mg if the drug was not administered again?
- A. 1 hours after the original dose
- B. 2 hours after the original dose
- C. 3 hours after the original dose
- D. 4 hours after the original dose
Correct Answer: C
Rationale: The half-life of a drug is the time it takes for the amount of drug in the body to decrease to one-half of the peak level it previously achieved. At a dose of 500 mg the drug level would be 250 mg in 1 hour, 125 mg in 2 hours, 62.5 mg in 3 hours, and 31.25 mg in 4 hours so the correct answer is 3 hours.
Thyroxin is contributed in all listed processes except one:
- A. Increase tissue demand of oxygen consumption
- B. Activating protein, carbohydrates and fats metabolism
- C. Increase the main metabolism
- D. Decrease the main metabolism
Correct Answer: D
Rationale: Thyroxine (T4) increases metabolism, not decreases it, by enhancing oxygen use and nutrient breakdown.