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Patients with septic shock are treated, among other drugs, with activated protein C. The purpose of this treatment is to
- A. Dampen the cytokine storm
- B. Raise the blood pressure
- C. Resolve DIC (disseminated intravascular coagulation)
- D. Boost the immune response
Correct Answer: C
Rationale: The correct answer is C: Resolve DIC. Activated protein C is used in septic shock to address the coagulopathy associated with DIC, a common complication. Activated protein C inhibits clotting factors and promotes fibrinolysis, helping to restore normal coagulation function. This treatment does not directly dampen the cytokine storm (choice A), raise blood pressure (choice B), or boost the immune response (choice D) in septic shock patients. It specifically targets the coagulation abnormalities seen in DIC, making choice C the most appropriate answer.
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What is the significance of HER2 positivity in breast cancer?
- A. Indicates aggressive tumor behavior and potential resistance to certain treatments
- B. Signifies slower tumor growth
- C. Indicates sensitivity to hormone therapy
- D. Denotes a benign tumor
Correct Answer: A
Rationale: HER2 positivity signifies aggressive tumor behavior and potential resistance to certain treatments, requiring targeted therapies.
Mature naïve T cells that leave the thymus
- A. Are all tolerant to self-antigens because all self-reactive developing T cells have been killed in the thymus
- B. Might include some self-reactive T cells that have not been tolerized against a specific Ag
- C. Go first to LN where they acquire the ability to recognize antigen presented by MHC
- D. Go first to LN to be tested for self-reactivity
Correct Answer: B
Rationale: The correct answer is B because mature naïve T cells that leave the thymus can include self-reactive T cells that have not been tolerized against a specific antigen. This is because the process of negative selection in the thymus eliminates most self-reactive T cells but does not catch all of them. Some self-reactive T cells may escape negative selection and circulate as mature naïve T cells. Therefore, it is possible for mature naïve T cells leaving the thymus to include self-reactive T cells that have not been tolerized against a specific antigen.
Choices:
A: This is incorrect because although negative selection in the thymus eliminates most self-reactive T cells, it does not catch all of them, so some self-reactive T cells may still be present in the mature naïve T cell population.
C: This is incorrect because mature naïve T cells already have the ability to recognize antigens presented by MHC, which is developed in the th
A patient who has received a kidney transplant has been admitted to the medical unit with acute rejection and is receiving IV cyclosporine (Sandimmune) and methylprednisolone (Solu-Medrol). Which staff member is best to assign to care for this patient?
- A. An RN who floated to the medical unit from the coronary care unit for the day.
- B. An RN with 3 years of experience in the operating room who is orienting to the medical unit.
- C. An RN who has worked on the medical unit for 5 years and is working a double shift today.
- D. A new graduate RN who needs experience with IV medication administration.
Correct Answer: C
Rationale: An experienced RN who is familiar with the medical unit and its protocols is the best choice for caring for a patient with acute rejection. This patient requires close monitoring and skilled care which an experienced RN can provide. The other options involve RNs who may not be as familiar with the unit or are less experienced.
One of the most significant factors in determining when to start antiretroviral therapy in a patient with HIV infection is:
- A. Whether the patient has high levels of HIV antibodies
- B. Confirmation that the patient has contracted HIV infection
- C. The patient’s readiness to commit to a complex, lifelong, uncomfortable drug regimen
- D. Whether the patient has a support system to help manage the costs and side effects of the drugs
Correct Answer: C
Rationale: Patient adherence is critical for successful antiretroviral therapy. Ensuring the patient is prepared to follow the regimen long-term improves outcomes.
What is a significant consequence of the evolutionary arms race between hosts and pathogens?
- A. Pathogens evolve slower than hosts
- B. Hosts develop epigenetic changes for immune adaptation
- C. Mutations in hosts always outpace pathogen evolution
- D. Hosts and pathogens remain static in their interactions
Correct Answer: B
Rationale: The correct answer is B because hosts developing epigenetic changes for immune adaptation is a significant consequence of the evolutionary arms race between hosts and pathogens. This adaptation allows hosts to better defend against evolving pathogens over time. This process is dynamic, as both hosts and pathogens continuously evolve in response to each other.
Choice A is incorrect because pathogens can evolve rapidly to adapt to host defenses. Choice C is incorrect because while hosts may have mutations that provide advantages, pathogens can also evolve to overcome host defenses. Choice D is incorrect as the interaction between hosts and pathogens is characterized by constant adaptation and change, not remaining static.