Nokea
A 26-year-old lady with primary infertility presents with hot flashes, nausea and a palpable adnexal mass.
- A. Clomiphene
- B. Hydrochlorothiazide
- C. Furosemide
- D. Mifepristone
Correct Answer: A
Rationale: Clomiphene induces ovulation, with side effects including hot flashes and ovarian cysts.
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A 27-year-old male is admitted to the Emergency Department (ED) after a serious motorcycle accident. The patient has a head injury, abrasions covering the left side of his body, a broken left femur, and internal injuries that are not fully assessed at this time. He is transferred from the ED to the ICU. The nurse who is going to care for this patient in the ICU knows that one of their most important responsibilities in regard to drug therapy is what?
- A. Support vital functions
- B. Continue curative treatment
- C. Institute life-saving treatment
- D. Monitor the patient's response
Correct Answer: D
Rationale: Monitoring drug response ensures timely adjustments in critical care, optimizing therapy amidst multiple injuries.
As a clinical consultant for the Breathright drug research firm, you are given the task of using an in vitro assay to screen ten thousand drug analogs to find the most potent beta-2 receptor agonist. When analysing your data, the biomarker that you should screen for is:
- A. E max
- B. Emax
- C. EC50
- D. Half life
Correct Answer: C
Rationale: Potency is measured by EC50 (dose producing 50% of max effect); lower EC50 indicates higher potency.
Despite good blood pressure control, an NP might change a patient's drug from an angiotensin-converting enzyme (ACE) inhibitor to an angiotensin II receptor blocker (ARB) because the ARB:
- A. Is stronger than the ACE inhibitor
- B. Does not produce a dry, hacky cough
- C. Has no effect on the renal system
- D. Reduces sodium and water retention
Correct Answer: B
Rationale: ARBs lack the cough side effect common with ACE inhibitors.
Insulin medications are not administered per os because
- A. Are poorly absorbed in GI truct
- B. They are breaksdown by the action of dygestive enzymes
- C. Increase glucose absorbtion
Correct Answer: B
Rationale: Insulin is a peptide broken down by digestive enzymes, rendering oral administration ineffective.
Anti-inflammatory action of glucocorticoids is determined by:
- A. Inhibition of phospholipase A2
- B. Activation of phospholipase A2
- C. Inhibition of cyclooxygenase type-1
- D. Inhibition of cyclooxygenase type-2
Correct Answer: A
Rationale: Glucocorticoids inhibit phospholipase A2, reducing the production of inflammatory mediators like prostaglandins.