Genitourinary System Assessment Related

Review Genitourinary System Assessment related questions and content

A 70 year old man has severe urinary hesitancy associated with BPH. He has tried alpha blockers with little effect. His physician recommends a drug that blocks 5α-reductase in the prostate which is:

  • A. Leuprolide
  • B. Finasteride
  • C. Flutamide
  • D. Ketoconazole
Correct Answer: B

Rationale: The correct answer is B: Finasteride. Finasteride is a 5α-reductase inhibitor that reduces the conversion of testosterone to dihydrotestosterone in the prostate, thereby shrinking the prostate gland and improving urinary symptoms in BPH. Leuprolide (A) is a GnRH agonist used in prostate cancer, not BPH. Flutamide (C) is an antiandrogen used in prostate cancer. Ketoconazole (D) is an antifungal drug and not indicated for BPH.