Health Assessment Neurological System Questions Related

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A 70-year-old patient taking carbidopa/levodopa 25/100 mg three times a day for PD is experiencing end-of-dose wearing off. The best next step is to:

  • A. Add tolcapone.
  • B. Consider surgery.
  • C. Add trihexyphenidyl.
  • D. Increase carbidopa/levodopa to four times daily.
Correct Answer: A

Rationale: Adding tolcapone, a COMT inhibitor, can help manage wearing-off symptoms by prolonging the effect of levodopa.