Health Promotion and Maintenance NCLEX PN Questions Related

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A client has been taking a drug (Drug A) that is highly metabolized by the cytochrome p-450 system. He has been on this medication for 6 months. At this time, he is started on a second medication (Drug B) that is an inducer of the cytochrome p-450 system. You should monitor this client for:

  • A. increased therapeutic effects of Drug A.
  • B. increased adverse effects of Drug B.
  • C. decreased therapeutic effects of Drug A.
  • D. decreased therapeutic effects of Drug B.
Correct Answer: C

Rationale: Drug B induces the cytochrome p-450 enzyme system of the liver, thus increasing the metabolism of Drug A, reducing its therapeutic effects.