Nokea
A drug with a half-life of 4 hours is administered at a dosage of 100 mg. How much of the drug will be in the patient's system 8 hours after administration?
- A. 75 mg
- B. 50 mg
- C. 37.5 mg
- D. 25 mg
Correct Answer: D
Rationale: The half-life of a drug is the time it takes for the amount of drug in the body to decrease to 1 half the peak level it previously achieved. Option A would occur 2 hours after administration of the drug. Option B would occur at 4 hours. Option C would occur at 6 hours. Option D would occur at 8 hours after the original administration of the drug.
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A 7-year-old male fell off a wood pile while playing. He has been admitted to the ICU with multiple broken bones and internal bleeding. What should the nurse know about drug therapy in this type of patient?
- A. Adverse effects may be decreased
- B. Therapeutic effects may be increased
- C. Pharmacodynamics may be altered
- D. Pharmacokinetics remain the same
Correct Answer: C
Rationale: Trauma alters pharmacodynamics (drug effects) due to physiological stress and injury responses.
Vincristine toxicity frequently presents as:
- A. Anemia
- B. Neutropenia
- C. Thrombocytopenia
- D. Polyneuritis
Correct Answer: D
Rationale: Vincristine commonly causes neurotoxicity, including polyneuritis.
A 75-year-old woman with diabetes is taking an oral antidiabetic drug. One day she goes without eating for 18 \mathrm{~h}. Her serum glucose concentration is 48 \mathrm{mg} / \mathrm{dL} (hypoglycemic) upon arrival at the emergency department, where she is deemed to be in critical condition. Which of the following drugs most likely aggravated this fasting hypoglycemia?
- A. Acarbose
- B. Glyburide
- C. Metformin
- D. Pioglitazone
Correct Answer: B
Rationale: Glyburide, a sulfonylurea, can cause severe hypoglycemia, especially during fasting, due to prolonged insulin release.
The nursing instructor observes several nursing students administer medications to their assigned patients. The instructor would stop what student from administering the medication until the error was corrected?
- A. The student checks the label on the medication against the administration record three times.
- B. The student enters the patient's room and asks the patient Are you Mr. Jones?
- C. The student checks the drug's brand name and generic name before taking it to the patient.
- D. The student documents the medication upon exiting the patient's room
Correct Answer: B
Rationale: Asking 'Are you Mr. Jones?' risks misidentification; students must verify identity with two identifiers (e.g., wristband).
A nurse is providing instructions to a client who has been experiencing Insomnia and has a new prescription for Temazepam. The nurse should inform the client that which of the following manifestations are adverse effects of temazepam? (Select one that does not apply.)
- A. Incoordination
- B. Hypertension
- C. Amnesia
- D. Sleep driving
Correct Answer: B
Rationale: Temazepam can cause incoordination , sleep driving , and amnesia , common benzodiazepine effects.