A nurse is planning to administer IV Alteplase to a client who is demonstrating manifestations of a massive Pulmonary Embolism. Which of the following interventions should the nurse plan to take?
- A. Administer IM Enoxaparin along with the Alteplase dose.
- B. Hold direct pressure on puncture sites for up to 30 min.
- C. Administer Aminocaproic acid IV prior to alteplase infusion.
- D. Prepare to administer Alteplase within 8 hr of manifestation onset.
Correct Answer: B
Rationale: Holding pressure prevents bleeding at puncture sites after alteplase, a thrombolytic.
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Pharmacokinetics is:
- A. The study of biological and therapeutic effects of drugs
- B. The study of absorption, distribution, metabolism and excretion of drugs
- C. The study of mechanism of drugs
- D. The study of methods of new drug development
Correct Answer: B
Rationale: Pharmacokinetics focuses on how the body handles a drug, including absorption, distribution, metabolism, and excretion (ADME), distinguishing it from pharmacodynamics, which studies drug effects.
A nurse is preparing a client's medications. Which of the following actions should the nurse take in following legal practice guidelines? (Select ONE that does not apply.)
- A. Maintain skill competency.
- B. Determine the dosage.
- C. Monitor for adverse effects.
- D. Safeguard medications.
Correct Answer: B
Rationale: Nurses must maintain competency , monitor effects , and safeguard meds ; determining dosage is the prescriber's role.
Diane may benefit from cyclosporine (Sandimmune). Cyclosporin may be prescribed to:
- A. Treat rheumatoid arthritis
- B. Treat patients with corn allergy
- C. Pregnant patients
- D. Treat patients with liver dysfunction
Correct Answer: A
Rationale: Cyclosporine treats rheumatoid arthritis; corn allergy , pregnancy , or liver issues are not indications.
The nurse is caring for a patient who takes several drugs. What patient would the nurse monitor most closely because of an increased risk for adverse effects of medications?
- A. The school-aged child
- B. The obese middle-aged man
- C. The adolescent
- D. The newborn infant
Correct Answer: D
Rationale: Newborns have immature organs, increasing risk for adverse effects from multiple drugs.
A patient presents in the emergency department with a massive overdose of a drug. The most worrisome signs and symptoms include excessive cardiac stimulation (severe tachycardia, palpitations, angina, etc.). The EDphysician orders IV administration a -adrenergic blocker, saying (correctly) it is the only drug likely to normalize cardiac function quickly and save the patient's life. Which of the following was the most likely drug the patient overdosed on?
- A. A second-generation sulfonylurea (e.g., glipizide, glyburide)
- B. Insulin
- C. Levothyroxine
- D. Prednisone (oral glucocorticoid)
Correct Answer: C
Rationale: Levothyroxine overdose causes thyrotoxicosis, leading to cardiac overstimulation treatable with beta-blockers.