A nurse is preparing to administer a prescribed drug via an intramuscular injection. Which of the following would be most appropriate for the nurse to do? (Select one that does not apply.)
- A. Always wear gloves.
- B. Cleanse skin at injection site.
- C. Place pressure on the area after removing the needle.
- D. Recap the needle before disposal.
Correct Answer: D
Rationale: When administering an intramuscular injection, the nurse should always wear gloves, cleanse the skin at the injection site prior to administration, aspirate for 5 to 10 seconds after inserting the needle, apply pressure to the area after removing the needle, and never recap the needle.
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Carbamazepine has a Black Box Warning due to life-threatening:
- A. Renal toxicity, leading to renal failure
- B. Hepatotoxicity, leading to liver failure
- C. Dermatologic reaction, including Steven's Johnson and toxic epidermal necrolysis
- D. Cardiac effects, including supraventricular tachycardia
Correct Answer: C
Rationale: Carbamazepine's Black Box Warning highlights severe skin reactions like SJS/TEN.
Which of the following mechanisms most accurately describes the blocking action of methimazole?
- A. iodine uptake by the thyroid
- B. organification of iodine in the thyroid
- C. peripheral conversion of T4 to T3
- D. peripheral thyroxine (T4) and T3 receptors
Correct Answer: B
Rationale: Methimazole inhibits thyroperoxidase, blocking iodine organification and thyroid hormone synthesis.
Tetracycline needs to be given on an empty stomach because it chelates with:
- A. Calcium
- B. Magnesium
- C. Iron
- D. All of the above
Correct Answer: D
Rationale: Tetracycline forms insoluble complexes with divalent and trivalent cations (calcium, magnesium, iron), reducing absorption when taken with food containing these elements.
Which legislation authorizes the FDA to determine the safety of a drug before its marketing?
- A. Federal Food, Drug, and Cosmetic Act (1938)
- B. Durham Humphrey Amendment (1952)
- C. Controlled Substances Act (1970)
- D. Kefauver Harris Drug Amendment (1962)
Correct Answer: A
Rationale: The Federal Food, Drug, and Cosmetic Act of 1938 authorized the FDA to determine the safety of all drugs before marketing. Later amendments and acts helped tighten FDA control and ensure drug safety.
Prior to prescribing metformin, the provider should:
- A. Draw a serum creatinine to assess renal function
- B. Try the patient on insulin
- C. Tell the patient to increase iodine intake
- D. Have the patient stop taking any sulfonylurea to avoid dangerous drug interactions
Correct Answer: A
Rationale: Metformin requires renal function assessment (creatinine) due to lactic acidosis risk; insulin isn't a prerequisite.
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