A patient with severe infectious disease is being treated with aminoglycoside * antibiotics. Which of the following diuretic should be avoided for this patient because of the serious side effect shared by both drugs?
- A. Furosemide
- B. Hydrochlorothiazide
- C. Spironolactone
- D. Acetazolamide
Correct Answer: A
Rationale: The correct answer is A: Furosemide. Aminoglycoside antibiotics can cause ototoxicity and nephrotoxicity. Furosemide, a loop diuretic, also has the potential to cause ototoxicity and nephrotoxicity, leading to a serious side effect when combined with aminoglycosides. On the other hand, choices B, C, and D (Hydrochlorothiazide, Spironolactone, and Acetazolamide) do not share the same serious side effects with aminoglycosides. Hydrochlorothiazide is a thiazide diuretic that acts on the distal convoluted tubule, Spironolactone is a potassium-sparing diuretic that acts on the collecting duct, and Acetazolamide is a carbonic anhydrase inhibitor diuretic that works in the proximal tubule. Therefore, Furosemide should
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Which one of the following bactericidal antimycobacterial drugs binds to S12 * ribosomal subunit inhibiting protein synthesis when injectable drug is needed and also effective against drug-resistant tuberculosis drug, can cause ototoxicity and nephrotoxicity?
- A. Streptomycin
- B. Ethambutol
- C. Isoniazid
- D. Rifampicin
Correct Answer: A
Rationale: The correct answer is A: Streptomycin. Streptomycin binds to the S12 ribosomal subunit, inhibiting protein synthesis in Mycobacterium tuberculosis. It is effective against drug-resistant tuberculosis and is used as an injectable drug. Streptomycin can cause ototoxicity and nephrotoxicity as side effects.
Choice B: Ethambutol primarily inhibits cell wall synthesis and can cause optic neuritis.
Choice C: Isoniazid inhibits mycolic acid synthesis and can cause hepatotoxicity.
Choice D: Rifampicin inhibits DNA-dependent RNA polymerase and can cause hepatotoxicity and drug interactions.
Which is incorrect of renal transplant patients?
- A. Identical twin donor and recipient, require no immunosuppression..
- B. Graft rejection may present with graft tenderness, decreased urine output and increased
- D. Infection is the most common cause of morbidity and mortality in the early stages, with 80% developing infection in the first year.
Correct Answer: A
Rationale: Correct Answer: A
Rationale: Identical twin donor and recipient still require immunosuppression due to minor histocompatibility antigens. Failure to suppress the immune system can lead to rejection. Graft rejection may present with symptoms such as graft tenderness, decreased urine output, and increased creatinine levels. Infections are indeed a common cause of morbidity and mortality in renal transplant patients, with a high incidence within the first year post-transplant. Therefore, choice A is incorrect as even identical twin donors and recipients require immunosuppression to prevent rejection.
A 5 year old child has been brought with intestinal obstruction due to clumping of roundworms. Which of the following anthelmintic which administered by orogastric tube can relax the balls of ascaris and relieve the obstruction?
- A. Levamisole
- B. Mebendazole
- C. Pyrantel pamoate
- D. Piperazine
Correct Answer: D
Rationale: The correct answer is D: Piperazine. Piperazine is a paralytic agent that causes relaxation of the muscles of the roundworm (Ascaris), allowing it to be easily expelled from the intestine. By administering piperazine via orogastric tube, the clumped roundworms causing intestinal obstruction can be relaxed, relieving the obstruction. Levamisole, Mebendazole, and Pyrantel pamoate are not effective in relaxing the muscles of the roundworms, making them incorrect choices for this specific scenario.
The process by which water is reabsorbed by following solutes when they are reabsorbed is called
- A. obligatory water reabsorption
- B. facultative water reabsorption
- C. osmotic water reabsorption
- D. renin-angiotensin water reabsorption
Correct Answer: B
Rationale: The correct answer is B: facultative water reabsorption. This process occurs in the collecting ducts of the nephron in the kidney, where water reabsorption is regulated based on the body's hydration levels. When solutes like sodium are reabsorbed, water follows passively through aquaporin channels, adjusting the amount of water reabsorbed according to the body's needs.
A: Obligatory water reabsorption refers to the constant reabsorption of water in the proximal tubule and descending loop of Henle, not regulated based on hydration levels.
C: Osmotic water reabsorption is a general term referring to the movement of water based on osmotic gradients, not specifically regulated by solute reabsorption.
D: Renin-angiotensin water reabsorption involves the renin-angiotensin-aldosterone system in response to low blood pressure, focusing on sodium reabsorption rather than direct regulation of
The inability of the kidneys to excrete adequately to maintain homeostasis is:
- A. glomerulonephritis.
- B. polycystic kidney diseas
- D. renal failur
Correct Answer: D
Rationale: The correct answer is D: renal failure. Renal failure refers to the kidneys' inability to adequately excrete waste products and maintain electrolyte balance, leading to disruption of homeostasis. Glomerulonephritis (A) is inflammation of the glomeruli, not necessarily resulting in inadequate excretion. Polycystic kidney disease (B) is a genetic disorder causing cysts in the kidneys, but it doesn't directly relate to excretory function. Choice C is incomplete.