Nokea
A pharmaceutical lab states that a drug causes negative side effects in 3 of every 100 patients. To confirm this affirmation, another laboratory chooses 5 people at random who have consumed the drug. What is the probability that at least two experience side effects?
- A. 0.8687
- B. 0.1313
- C. 0.00847
- D. 0.0003
Correct Answer: C
Rationale: The probability of at least two experiencing side effects is P(X≥2) = 1 - [P(X=0) + P(X=1)]. Using binomial calculations: P(X=0) = 0.8687, P(X=1) = (5 choose 1) * 0.03 * 0.97^4 = 0.1342, so P(X≥2) = 1 - (0.8687 + 0.1342) = 0.00847, matching the document.
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Which of the following adverse effects of chronic high-dose prednisone administration represents a mineralocorticoid effect?
- A. Buffalo hump
- B. Easy bruising
- C. Edema
- D. Moon facies
Correct Answer: C
Rationale: Edema is a mineralocorticoid effect of prednisone due to sodium and water retention.
In the presence of pentazocine, a higher concentration of morphine is required to elicit pain relief. Pentazocine by it self has a smaller analgesic effect than does morphine, even at the highest dose, Which of the following is correct regarding these medications?
- A. Pentazocine is a competitive antagonist
- B. Morphine is a full agonist, and pentazocine is a partial agonist
- C. Morphine is less efficacious than is pentazocine
- D. Morphine is less potent than is pentazocine
Correct Answer: B
Rationale: Pentazocine's submaximal effect and antagonism of morphine indicate it is a partial agonist, while morphine is a full agonist.
Which of the following does albumin have the strongest affinity for?
- A. Anionic drugs
- B. Hydrophilic drugs
- C. Hydrophobic drugs
- D. A and C
Correct Answer: C
Rationale: Albumin has the strongest affinity for hydrophobic drugs , which bind to its hydrophobic pockets, unlike hydrophilic drugs; anionic drugs may bind but less preferentially.
A nurse is assessing a client who is taking Amiodarone to treat Atrial Fibrillation. Which of the following findings is a manifestation of Amiodarone toxicity?
- A. Light yellow urine
- B. Report of tinnitus
- C. Productive cough
- D. Blue-gray skin discoloration
Correct Answer: C
Rationale: Productive cough may indicate pulmonary toxicity, a serious amiodarone side effect.
After teaching a group of nursing students about pharmacokinetics, the instructor determines that the teaching was successful when the students identify which of the following as a phase? (Select one that does not apply.)
- A. Absorption
- B. Distribution
- C. Administration
- D. Metabolism
Correct Answer: C
Rationale: The pharmacokinetic phases are absorption, distribution, metabolism, and excretion. The acronym ADME is a helpful way to remember the pharmacokinetic phases.