Nokea
After 4 months of treatment for tuberculosis the patient began complaining of toes and fingers numbness, sensation of creeps. He was diagnosed with polyneuritis. What antituberculous drug might have caused these complications?
- A. Isoniazid
- B. Rifampicin
- C. Ciprofloxacin
- D. Sodium salt of benzylpenicillin
Correct Answer: A
Rationale: The correct answer is A: Isoniazid. Isoniazid is known to cause peripheral neuropathy as a side effect, especially with prolonged use. It can lead to symptoms such as numbness, tingling, and weakness in the toes and fingers due to its neurotoxic effects. Rifampicin (B) is less likely to cause neuropathy. Ciprofloxacin (C) is not typically associated with neuropathy. Sodium salt of benzylpenicillin (D) is an antibiotic but is not known to cause polyneuritis.
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Allergy to penicillin is an example of:
- A. Type I hypersensitivity reaction
- B. Type II hypersensitivity reaction
- C. Type III hypersensitivity reaction
- D. Type IV hypersensitivity reaction
Correct Answer: A
Rationale: Step-by-step rationale for choice A being correct:
1. Penicillin allergy involves IgE antibodies binding to penicillin.
2. This triggers mast cell degranulation, releasing histamine.
3. Histamine causes allergic symptoms like rash, swelling.
4. This immune response characterizes Type I hypersensitivity reactions.
Summary of other choices:
B: Type II reactions involve antibody-mediated cell destruction, not seen in penicillin allergy.
C: Type III reactions involve immune complex deposition, not typical in penicillin allergy.
D: Type IV reactions are delayed hypersensitivity reactions, not immediate like penicillin allergy.
Disinfection with chemicals acting on cell surface:
- A. Soaps
- B. Phenols
- C. Amines
- D. Polymyxin
Correct Answer: B
Rationale: The correct answer is B: Phenols. Phenols act on the cell surface by disrupting cell membranes and denaturing proteins, leading to cell death. Soaps (A) work by lifting dirt and microbes off surfaces, not directly acting on cell surfaces. Amines (C) are typically used as disinfectants targeting specific enzymes in microbes, not cell surfaces. Polymyxin (D) is an antibiotic that works by disrupting cell membranes internally, not on the cell surface.
The bacteria that produces a thick pseudomembrane in the throat is:
- A. Corynebacterium diphtheriae
- B. Streptococcus pyogenes
- C. Neisseria meningitidis
- D. Bacillus cereus
Correct Answer: A
Rationale: Rationale:
1. Corynebacterium diphtheriae is the correct answer as it is the bacteria responsible for causing diphtheria, characterized by a thick pseudomembrane in the throat.
2. Streptococcus pyogenes causes strep throat but does not produce a pseudomembrane.
3. Neisseria meningitidis causes meningitis and septicemia, not a throat pseudomembrane.
4. Bacillus cereus causes food poisoning, not throat-related symptoms.
A patient consulted a doctor about bowels disfunction. The doctor established symptoms of duodenitis and enteritis. Laboratory examination helped to make the following diagnosis: lambliosis. What medication should be administered?
- A. Metronidazole
- B. Erythromycin
- C. Monomycin
- D. Chingamin
Correct Answer: A
Rationale: Rationale: Metronidazole is the drug of choice for treating lambliosis due to its effectiveness against Giardia lamblia, the parasite causing the infection. Metronidazole works by disrupting the DNA structure of the parasite, leading to its death. Erythromycin (choice B) is not effective against Giardia lamblia. Monomycin (choice C) and Chingamin (choice D) are not commonly used for treating lambliosis. Therefore, choice A, Metronidazole, is the correct medication for this patient.
The suffix -virales is given to the following terms within the taxon
- A. Species
- B. Order
- C. Family
- D. Genus
Correct Answer: B
Rationale: The correct answer is B: Order. The suffix -virales is used in virology to denote the order level in the taxonomy of viruses. Orders are higher taxonomic ranks compared to species, family, and genus. The suffix -virales is specifically assigned to virus orders, making choice B the correct one. The other choices (A, C, D) are incorrect because the suffix -virales does not apply to species, family, or genus in the taxonomic classification of viruses.