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After teaching a group of nursing students about pharmacokinetics, the instructor determines that the teaching was successful when the students identify which of the following as the first phase?
- A. Metabolism
- B. Absorption
- C. Distribution
- D. Excretion
Correct Answer: B
Rationale: Pharmacokinetics refers to the transportation activity of drugs in the body after administration. The first component is absorption. This is followed by distribution, metabolism, and finally excretion.
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After teaching a group of nursing students about pharmacokinetics, the instructor determines that the teaching was successful when the students identify which of the following as the site for the metabolism of most drugs?
- A. Liver
- B. Lungs
- C. Kidneys
- D. Intestinal mucosa
Correct Answer: A
Rationale: Although the kidneys, lungs, plasma, and intestinal mucosa may aid in the metabolism of drugs, most drugs are metabolized by the liver.
A nursing student is preparing to administer a prescribed drug to a patient. The student reviews information about the drug and its actions. Which of the following would be the best choice for obtaining this information? Select all that apply.
- A. Nursing instructor
- B. Nurse assigned to the patient
- C. Clinical drug reference
- D. Prescribing health care provider
- E. Clinical pharmacist
Correct Answer: C,E
Rationale: Although the nursing student can ask the nursing instructor, the nurse assigned to the patient, and the prescribing health care provider for information about the drug, the best choices for drug information would include an appropriate drug reference and the clinical pharmacist.
A nurse has administered drugs to a patient as per the physician's orders. Which of the following activities should the nurse perform after administering the prescribed drugs to the patient?
- A. Record symptoms of the condition.
- B. Perform a culture and sensitivity test.
- C. Obtain history of drug allergy.
- D. Check for adverse drug reactions.
Correct Answer: D
Rationale: After administering the drug to the patient, the nurse should observe the patient for adverse drug reactions. Recording symptoms of infection, performing a culture and sensitivity test, and obtaining a history of drug allergy are typically performed by the nurse in the preadministration assessment stage.
A patient wants to know about the possible interactions of the various drugs that he has been prescribed for an illness. The nurse explains that the drugs interact with each other and produce an effect that is greater than the sum of their separate actions. Which of the following reactions is the nurse informing about?
- A. Additive drug reaction
- B. Synergistic drug reaction
- C. Antagonistic drug reaction
- D. Toxic drug reaction
Correct Answer: B
Rationale: A synergistic drug reaction occurs when drugs interact with each other and produce a sum greater than the sum of their separate actions. An additive drug reaction occurs when the combined effect of two drugs is equal to the sum of each drug given alone. An antagonistic drug reaction occurs when one drug interferes with the action of another, causing neutralization or a decrease in the effect of one drug. Toxic drug reactions are caused when blood concentration levels exceed the therapeutic levels of a drug.
The nurse administers a prescribed medication that is supplied as an enteric-coated tablet. The patient asks the nurse about this form of tablet. When describing how this tablet is absorbed, which response by the nurse would be most accurate?
- A. The medication dissolves directly from the stomach into the body.
- B. The drug breaks up into pieces as it moves through the stomach.
- C. The medication bypasses the GI tract and goes quickly into the bloodstream.
- D. The drug dissolves into fragments after it reaches your small intestine.
Correct Answer: D
Rationale: Enteric-coated tablets disintegrate or fragment after reaching the alkaline medium of the small intestine. Tablets and capsules break up into small particles and dissolve into body fluids in the gastrointestinal tract. Liquids and parenteral drugs are quickly absorbed into the body system.