Nokea
AH are prodrugs except
- A. Enalapril
- B. Paracetamol
- C. Sulphamethoxazole
- D. Trimethoprim
Correct Answer: D
Rationale: Enalapril is a prodrug; paracetamol, sulphamethoxazole, and trimethoprim are active drugs.
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Tamoxifen is prescribed for the client with metastatic breast carcinoma. The nurse understands that the primary action of this medication is to:
- A. Increase DNA and RNA synthesis.
- B. Promote the biosynthesis of nucleic acids.
- C. Increase estrogen concentration and estrogen response.
- D. Compete with estradiol for binding to estrogen in tissues containing high concentrations of receptors.
Correct Answer: D
Rationale: Tamoxifen is an antineoplastic medication that competes with estradiol for binding to estrogen in tissues containing high concentrations of receptors. Tamoxifen is used to treat metastatic breast carcinoma in women and men. Tamoxifen is also effective in delaying the recurrence of cancer following mastectomy. Tamoxifen reduces DNA synthesis and estrogen response.
The patient tells the nurse about a new drug being tested to treat the disease she was diagnosed with and asks the nurse whether the doctor can prescribe a medication still in the preclinical phase of testing. What is the nurse's best response?
- A. The doctor would have to complete a great deal of paperwork to get approval to prescribe that drug.
- B. Sometimes pharmaceutical companies are looking for volunteers to test a new drug and the doctor could give them your name.
- C. Drugs in the preclinical phase of testing are only tested on animals and so would not be available to you.
- D. Drugs in the preclinical phase of testing are given only to healthy young men and so would not be available to you.
Correct Answer: C
Rationale: During the preclinical phase of testing drugs are tested on animals and are not available to patients. In phase I, the drug is tested on volunteers who are usually healthy young men. It is only in phase III studies that the drug is made available to prescribers who agree to closely monitor patients getting the medication.
Children who should receive meningococcal conjugate vaccine (Hib-MenCY, MenHibrix) include:
- A. Children traveling to the Haj
- B. Infants, routinely at 2, 4, 6, and 12 to 15 months
- C. Infants with functional asplenia (including sickle cell disease)
- D. Two-year olds with complement deficiencies
Correct Answer: C
Rationale: Hib-MenCY is indicated for infants with asplenia (e.g., sickle cell); Haj travel applies to older meningococcal vaccines.
NSAIDs combat fever by inhibiting which prostaglandin?
- A. Prostaglandin E2
- B. Prostaglandin I2
- C. Prostaglandin D2
- D. Prostaglandin F2
Correct Answer: A
Rationale: Prostaglandin E2 mediates fever in the hypothalamus; NSAIDs reduce fever by inhibiting its synthesis.
The nurse is applying the Centers for Disease Control and Prevention (CDC) recommendations for the possibility of bioterrorism. What action should the nurse perform?
- A. Post updated information on signs and symptoms of infections caused by biological agents
- B. Provide guidelines for treating clients exposed to, or potentially exposed to, biological agents
- C. Remain current on recognition and treatment of infections caused by biological weapons
- D. Advocate for increased funding for research involving bioterrorism and client treatment
Correct Answer: C
Rationale: Staying current on recognition and treatment aligns with CDC recommendations for nurse preparedness in bioterrorism scenarios.