Nokea
All of the following are adverse effects of phenothiazines except
- A. Rigidity and tremor
- B. Menstrual irregularities
- C. Cholestatic jaundice
- D. Systolic hypertension
Correct Answer: D
Rationale: Phenothiazines cause hypotension, not hypertension.
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Therapeutic index of a drug is an indicator of
- A. Potency
- B. Safety
- C. Toxicity
- D. Efficacy
Correct Answer: C
Rationale: Therapeutic index (TD50/ED50) measures the margin between therapeutic and toxic doses.
Amphetamine should not be taken with.....
- A. Paracetamol
- B. Aspirin
- C. MAO inhibitors
- D. Benzimidazole
Correct Answer: C
Rationale: Amphetamines combined with MAO inhibitors can cause a hypertensive crisis due to excessive catecholamine accumulation, a well-known dangerous interaction.
The reason that two MMR vaccines at least a month apart are recommended is:
- A. The second dose of MMR 'boosts' the immunity built from the first dose
- B. Two vaccines 1 month apart is the standard dosing for all live virus vaccines
- C. If the two MMR vaccine doses are given too close together there is a greater likelihood of severe localized reaction to the vaccine
- D. Only 95% of patients are fully immunized for measles after the first vaccine, with 99% having immunity after two doses of MMR
Correct Answer: D
Rationale: Two MMR doses ensure 99% immunity, as 95% respond to one dose; boosting is secondary to this goal.
Drugs bound to albumin are inactive.
- A. TRUE
- B. FALSE
Correct Answer: A
Rationale: True; drugs bound to albumin are inactive as only the free (unbound) fraction can interact with receptors or be metabolized/excreted.
A patient arrives in the emergency department in an acute state of alcohol intoxication and reports chronic consumption of several six packs of beer every day for the past year. The nurse anticipates administering which medication or treatment?
- A. Chlordiazepoxide (Librium)
- B. Disulfiram (Antabuse)
- C. Gastric lavage
- D. Vasoconstrictors
Correct Answer: A
Rationale: Chlordiazepoxide prevents alcohol withdrawal symptoms; disulfiram is post-detox. To prevent acute withdrawal and delirium tremens, a long-acting benzodiazepine, such as chlordiazepoxide, is given.