Nokea
Amphetamine should not be taken with.....
- A. Paracetamol
- B. Aspirin
- C. MAO inhibitors
- D. Benzimidazole
Correct Answer: C
Rationale: Amphetamines combined with MAO inhibitors can cause a hypertensive crisis due to excessive catecholamine accumulation, a well-known dangerous interaction.
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A nursing student is reviewing information about the Controlled Substances Act of 1970. The student would expect to find which of the following as being regulated for drugs classified as controlled substances? Select one that does not apply
- A. Manufacturing
- B. Elimination
- C. Distribution
- D. Dispensing the drug
Correct Answer: B
Rationale: The Controlled Substances Act of 1970 regulates the manufacture, distribution, and dispensing of drugs classified as controlled substances. Elimination refers to the excretion of drugs from the body, a pharmacokinetic activity. The act does not address formulation of the drug.
The student nurse asks the instructor why a patient with a central nervous system infection is receiving antibiotics that will not cross the blood-brain barrier. What is the instructor's most correct response?
- A. A severe infection alters the blood-brain barrier to allow the drug to cross.
- B. A medication that is water soluble is more likely to cross the blood-brain barrier.
- C. Antibiotics are the exception to the blood-brain barrier and cross easily.
- D. An infection that spreads outside the central nervous system helps drugs cross the barrier.
Correct Answer: A
Rationale: Effective antibiotic treatment can occur only when the infection is severe enough to alter the blood-brain barrier and allow antibiotics to cross. Lipid-soluble, not water-soluble, medications cross the blood-brain barrier more easily and most antibiotics are lipid soluble, so they are not the exception. No matter where the infection originates, drugs must cross the blood-brain barrier to treat central nervous system infections.
The following drug is not secreted in bile
- A. Penicillin
- B. Phenolphthalein
- C. Novobiocin
- D. Erythromycin
Correct Answer: A
Rationale: Penicillin is excreted via kidneys; others are secreted in bile.
Glucocorticoid effects of carbohydrate metabolism is facilitated with:
- A. Gluconeogenesis
- B. Hypoglicemia
- C. Enhance of glucose utilization with peripherial tissues
- D. Decrease of glycogen reserve in the liver
Correct Answer: A
Rationale: Glucocorticoids promote gluconeogenesis, increasing blood glucose levels by converting non-carbohydrate sources into glucose.
A patient with Type 2 diabetes mellitus begins gaining weight after several months of therapy with an oral antidiabetic agent. A complete workup indicates edema and other signs and symptoms of heart failure. Which of the following antidiabetic drug or group was the most likely cause?
- A. Acarbose
- B. Biguanides
- C. Glitazones (thiazolidinediones, such as rosiglitazone)
- D. Metformin
Correct Answer: C
Rationale: Glitazones like rosiglitazone can cause fluid retention and weight gain, increasing the risk of heart failure.