Nokea
An 18-year-old college student with an exacerbation of systemic lupus erythematosus (SLE) has been receiving prednisone (Deltacone) 20 mg daily for 4 days. Which of these medical orders should you question?
- A. Discontinue prednisone after today’s dose.
- B. Administer first dose of varicella vaccine.
- C. Check patient’s C-reactive protein (CRP).
- D. Give ibuprofen (Advil) 800 mg every 6 hours.
Correct Answer: B
Rationale: The varicella vaccine is a live vaccine and should not be given to patients who are immunosuppressed such as those receiving prednisone. The other orders are appropriate for managing SLE and its symptoms.
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Secondary lymphoid tissues are where:
- A. Lymphocyte precursors become mature
- B. Inflammation occurs during re-infection with a given pathogen
- C. Lymphocytes become activated by antigen
- D. Gene rearrangement takes place
Correct Answer: C
Rationale: The correct answer is C because secondary lymphoid tissues, like lymph nodes and spleen, are where lymphocytes encounter antigens and become activated. This process leads to the proliferation and differentiation of lymphocytes, enabling them to mount an immune response against specific pathogens. Choices A, B, and D are incorrect because A pertains to primary lymphoid tissues, B describes a localized immune response, and D refers to the process of gene rearrangement that occurs in the primary lymphoid tissues during lymphocyte development.
A structural domain essential for the assembly of the inflammasome is
- A. Leucine rich repeats
- B. TIR domain
- C. CARD
- D. All of the above
Correct Answer: C
Rationale: The correct answer is C: CARD. CARD stands for Caspase Activation and Recruitment Domain, which is crucial for the assembly of the inflammasome complex. It facilitates the recruitment and activation of caspase enzymes, leading to inflammatory responses. Leucine rich repeats (A) and TIR domain (B) are not directly involved in the assembly of the inflammasome. Therefore, the correct choice is C, as it specifically pertains to the structural domain essential for this process.
To prevent the debilitating cycle of fatigue-depression-fatigue in patients receiving radiation therapy, what should the nurse encourage the patient to do?
- A. Implement a walking program
- B. Ignore the fatigue as much as possible
- C. Do the most stressful activities when fatigue is tolerable
- D. Schedule rest periods throughout the day whether fatigue is present or not
Correct Answer: D
Rationale: Scheduled rest periods help break the cycle of fatigue and depression.
What is the primary advantage of the memory function in adaptive immunity?
- A. Rapid and stronger responses to previously encountered antigens
- B. Direct killing of pathogens without prior activation
- C. Enhanced cytokine secretion
- D. Resistance to all infections without exposure
Correct Answer: A
Rationale: The correct answer is A because memory function in adaptive immunity allows for rapid and stronger responses to previously encountered antigens. This is achieved through the presence of memory cells, such as memory B and T cells, which can quickly recognize and respond to specific pathogens upon re-exposure. This leads to a faster and more efficient immune response, providing better protection against future infections.
Choice B is incorrect because direct killing of pathogens without prior activation is a function of innate immunity, not adaptive immunity. Choice C is incorrect as enhanced cytokine secretion is not the primary advantage of memory function. Choice D is incorrect because while memory function provides protection against previously encountered antigens, it does not confer resistance to all infections without exposure.
The annotation D refers to which DNA component?
- A. Plasmid DNA
- B. Vector DNA
- C. Insert DNA
- D. Recombinant DNA
Correct Answer: D
Rationale: The correct answer is D: Recombinant DNA. Recombinant DNA refers to the DNA molecule formed by combining DNA from different sources. In genetic engineering, this is created by inserting a foreign DNA fragment into a vector DNA, resulting in a new DNA molecule. Plasmid DNA (A) is a small, circular DNA found in bacteria. Vector DNA (B) is a carrier molecule used to transport foreign DNA into a host cell. Insert DNA (C) is the DNA fragment that is inserted into a vector. Therefore, choice D is the correct answer as it specifically refers to the combined DNA molecule formed in genetic engineering.