Nokea
Many clients with chronic fatigue syndrome (CFS) report severe,ongoing fatigue without any explanation that has lasted for at least — months.
- A. 12
- B. 6
- C. 3
- D. 2
Correct Answer: B
Rationale: Chronic fatigue syndrome is characterized by severe unexplained fatigue lasting for at least six months.
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The patient with osteoporosis calls the nurse in the doctor's office to report that she should have taken but has forgotten to take her weekly bisphosphonate (alendronate [Fosamax]) that was due 2 days ago. How should the nurse advise the patient?
- A. "Take the dose now with 8 ounces of water."
- B. "Take two doses 3 days apart."
- C. "Skip this week and pick up the schedule next week."
- D. "Take two tablets now with a snack."
Correct Answer: C
Rationale: The correct answer is C: "Skip this week and pick up the schedule next week." Bisphosphonates like alendronate should be taken as directed, typically once weekly. It is important to maintain consistency in dosing to maximize effectiveness and minimize potential side effects. Taking a double dose or taking it late can increase the risk of side effects like gastrointestinal irritation or esophageal damage. Skipping a dose and resuming the schedule next week helps maintain the proper dosing interval. Options A and D suggest taking extra doses, which can be harmful. Option B of taking two doses 3 days apart is also incorrect as it deviates from the prescribed weekly schedule.
Which of the following nucleotide triplets best represents a codon?
- A. a triplet in the same reading frame as an upstream AUG.
- B. a triplet separated spatially from other triplets.
- C. a sequence in tRNA at the 3' end.
- D. a triplet that has no corresponding amino acid.
Correct Answer: A
Rationale: The correct answer is A because a codon is a triplet of nucleotides in mRNA that corresponds to a specific amino acid during protein synthesis. To be a codon, the triplet must be in the same reading frame as the start codon (AUG) to maintain the correct reading of the genetic code. Choice B is incorrect because codons are typically consecutive in mRNA. Choice C is incorrect as tRNA sequences are not codons. Choice D is incorrect because all codons correspond to specific amino acids.
What is the consequence of granzyme entering a target cell?
- A. Neutralization of toxins
- B. Activation of apoptosis pathways
- C. Inhibition of cytokine secretion
- D. Promotion of antigen presentation
Correct Answer: B
Rationale: Granzyme entering a target cell activates apoptosis pathways by inducing cell death. Firstly, granzyme activates caspases leading to cell death. Secondly, it triggers DNA fragmentation and cell shrinkage. Lastly, it enhances membrane blebbing and apoptotic body formation. The other choices are incorrect because granzyme does not neutralize toxins, inhibit cytokine secretion, or promote antigen presentation within a target cell.
What is the medical term for the formation of abnormal red blood cells?
- A. Leukocytosis
- B. Thrombocytosis
- C. Hemolysis
- D. Anemia
Correct Answer: D
Rationale: The correct answer is D: Anemia. Anemia is the medical term for a condition where there is a decrease in the number of red blood cells or hemoglobin in the blood. The formation of abnormal red blood cells can lead to anemia, affecting the oxygen-carrying capacity of the blood. Leukocytosis (A) is an increase in white blood cells, thrombocytosis (B) is an increase in platelets, and hemolysis (C) is the breakdown of red blood cells, none of which specifically refer to the formation of abnormal red blood cells.
Thymocytes undergoing positive selection express:
- A. TCR
- B. CD4
- C. CD8
- D. All of the above
Correct Answer: D
Rationale: Thymocytes undergoing positive selection express both CD4 and CD8 co-receptors along with a functional T-cell receptor (TCR). CD4 and CD8 help in recognizing MHC molecules, while TCR is crucial for antigen recognition. Positive selection ensures that thymocytes with a functional TCR that can interact with self-MHC molecules survive. Therefore, the correct answer is D, as thymocytes undergoing positive selection express TCR, CD4, and CD8. Choice A, TCR alone, is incorrect as CD4 and CD8 are also expressed. Choices B and C are incorrect as positive selection involves the expression of both CD4 and CD8, not just one or the other.