Nokea
Anthracycline (doxorubicin) on rare occasion causes acute inflammatory myocardial injury, but more classically results in dilated cardiomyopathy (DCM) in up to 30% of patients with a cumulative dose of doxorubicin exceeding
- A. 250 mg/m²
- B. 350 mg/m²
- C. 450 mg/m²
- D. 550 mg/m²
Correct Answer: D
Rationale: A cumulative dose of doxorubicin exceeding 550 mg/m² is associated with increased risk of dilated cardiomyopathy.
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Recognised causes of stroke in children include:
- A. Sickle cell disease
- B. Cystinuria
- C. SLE
- D. Left-to-right shunts
Correct Answer: A
Rationale: Sickle cell disease can cause stroke in children due to the sickled cells blocking blood flow to the brain.
The following are suggestive of abnormal language development:
- A. Not localising sound at 4 months of age
- B. No response to human words at 6 weeks
- C. Not understanding 'no' at 18 months of age
- D. Does not move to music at 2 years of age
Correct Answer: C
Rationale: Failure to understand simple commands like 'no' by 18 months is a red flag for abnormal language development.
The tricuspid valve is in closed position corresponding to which of the following curves of central venous pressure:
- A. a' wave
- B. x descent
- C. x' descent
- D. y descent
Correct Answer: B
Rationale: The tricuspid valve is closed during the x descent of the central venous pressure curve.
What is ONE gene mutation typically associated with Marfan’s syndrome?
- A. FBN1
- B. ACTA2
- C. SIX2
- D. TGFBR2
Correct Answer: A
Rationale: The FBN1 mutation is the most commonly identified genetic mutation associated with Marfan's syndrome.
Defects of complement system should be suspected in:
- A. Recurrent folliculitis
- B. Facial swelling following trauma
- C. Recurrent meningococcal infection
- D. Pneumocystis carinii pneumonia
Correct Answer: C
Rationale: Recurrent meningococcal infection: Defects in the complement system, especially the terminal complement components, increase the risk of recurrent meningococcal infections.