Nokea
Bismuth subsalicylate (Pepto Bismol) is a common OTC remedy for gastrointestinal complaints. Bismuth subsalicylate:
- A. May lead to toxicity if taken with aspirin
- B. Is contraindicated in children with flu-like illness
- C. Has antimicrobial effects against bacterial and viral enteropathogens
- D. All of the above
Correct Answer: D
Rationale: All apply: bismuth with aspirin risks salicylate toxicity , is contraindicated in kids with flu (B, Reye's syndrome), and has antimicrobial action .
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All the following statements regarding treatment of parkinson's disese are correct except
- A. Levodopa is usually administered alone (KAR93)
- B. Amantadine is effective in the treatment of early disease
- C. Bromocryptine is a useful dopamine receptor agonist
- D. Patient may require medication every 2 hours
Correct Answer: A
Rationale: Levodopa is typically combined with carbidopa, not given alone.
As a clinical consultant for the Breathright drug research firm, you are given the task of using an in vitro assay to screen ten thousand drug analogs to find the most potent beta-2 receptor agonist. When analysing your data, the biomarker that you should screen for is:
- A. E max
- B. Emax
- C. EC50
- D. Half life
Correct Answer: C
Rationale: Potency is measured by EC50 (dose producing 50% of max effect); lower EC50 indicates higher potency.
What is the fraction of unchanged drug reaching the systemic circulation?
- A. Elimination
- B. Bioavailability
- C. Metabolism
- D. Drug displacement
Correct Answer: B
Rationale: Bioavailability is defined as the fraction of unchanged drug that reaches systemic circulation, a key pharmacokinetic parameter.
The American Dietetic Association has recommended the use of specific nutritional supplements in the following population(s):
- A. 400 IU per day of vitamin D in all infants and children
- B. 1,000 IU per day of vitamin D for all pregnant women
- C. 60 mg per day of iron for all adults over age 50 years
- D. All of the above
Correct Answer: A
Rationale: The ADA recommends 400 IU/day of vitamin D for infants and children to support bone health.
A nurse is caring for a client who has a new prescription for Lithium Carbonate. When teaching the client about ways to prevent Lithium toxicity, the nurse should advise the client to do which of the following?
- A. Avoid the use of acetaminophen for headaches.
- B. Restrict intake of foods rich in sodium.
- C. Decrease fluid intake to less than 1,500 mL daily
- D. Limit aerobic activity in hot weather
Correct Answer: D
Rationale: Limiting activity in hot weather prevents dehydration, which increases lithium levels and risk of toxicity.