Chronic Disease Discussion Questions Related

Review Chronic Disease Discussion Questions related questions and content

Certain drug classes may cause harm in patients with symptomatic (NYHA classes II-IV) reduced ejection Heart failure (HFrEF), and thus should be avoided. If they are strongly indicated, they are to be used with caution, and with close monitoring. Such drugs include all of the following except:

  • A. Thiazolidinediones (glitazones, e.g., pioglitazone, rosiglitazone)
  • B. Nonsteroidal anti-inflammatory drugs and COX-2 inhibitors
  • C. Nutritional supplements (e.g., coenzyme Q10, carnitine, taurine, and antioxidants)
  • D. Non-dihydropyridine calcium-channel blockers (verapamil, diltiazem)
Correct Answer: C

Rationale: HFrEF hates fluid and strain glitazones swell, NSAIDs tank kidneys, verapamil/diltiazem slow too much, trastuzumab trashes hearts. Supplements like CoQ10? Neutral or helpful, not harmful, a safe outlier. Clinicians dodge the rest, easing chronic pump woes, not this add-on.