Nokea
Corticosteroids are acting on:
- A. Ion channels
- B. Thirosinkinase
- C. G-proteins
- D. genome and cases gene transcription
Correct Answer: D
Rationale: Corticosteroids act on the genome, binding to receptors that regulate gene transcription.
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Which of the following is not used for hyperthyroidism:
- A. Triiodthironine
- B. Mercazolil
- C. Diiodthironine
- D. Potassium iodide
Correct Answer: A
Rationale: Triiodothyronine (T3) is a thyroid hormone, not a treatment for hyperthyroidism, unlike the others.
A nurse is teaching a female client who has tobacco use disorder about Nicotine replacement therapy. Which of the following statements by the client indicates understanding of the teaching?
- A. I should avoid eating right before I chew a piece of nicotine gum.
- B. I will need to stop using the nicotine gum after 1 year.
- C. I know that nicotine gum is a safe alternative to resulting if I become pregnant.
- D. I must chew the nicotine gum quickly for about 15 minutes.
Correct Answer: A
Rationale: Avoiding food before chewing enhances nicotine absorption; gum isn't safe in pregnancy, and chewing is slow.
Lispro is an insulin analogue produced by recombinant DNA technology. Which of the following statements about this form of insulin is NOT true?
- A. Optimal time of preprandial injection is 15 minutes
- B. Duration of action is increased when the dose is increased
- C. It is compatible with neutral protamine Hagedorn insulin
- D. It has no pronounced peak
Correct Answer: B
Rationale: Lispro's duration is fixed (3-5 hours), not dose-dependent; 15-minute timing , NPH compatibility , and peakless profile are true.
Rifampin is a nonspecific CYP450 inducer that may:
- A. Lead to toxic levels of rifampin and must be monitored closely
- B. Cause toxic levels of drugs, such as oral contraceptives, when coadministered
- C. Induce the metabolism of drugs, such as oral contraceptives, leading to therapeutic failure
- D. Cause nonspecific changes in drug metabolism
Correct Answer: C
Rationale: Rifampin induces CYP450, speeding metabolism of drugs like oral contraceptives , reducing efficacy, not causing toxicity or nonspecificity .
Choose the correct statement about ondansetron:
- A. It is a dopamine D2 receptor antagonist
- B. It suppresses postoperative nausea and vomiting
- C. It is the most effective antiemetic for motion sickness
- D. It is not effective by oral route
Correct Answer: B
Rationale: Ondansetron, a 5-HT3 receptor antagonist, effectively suppresses postoperative nausea and vomiting; it's less effective for motion sickness and is effective orally.