Nokea
Cruciferous vegetables may alter drug pharmacokinetics by:
- A. Enhancing absorption of weakly acidic drugs
- B. Altering CYP 3A4 activity, leading to elevated levels of drugs, such as the statins
- C. Inducing CYP 1A2, possibly leading to therapeutic failure of drugs metabolized by CYP 1A2
- D. Decreasing first-pass metabolism of drugs
Correct Answer: C
Rationale: Cruciferous vegetables (e.g., broccoli) induce CYP1A2, accelerating metabolism of drugs like theophylline, potentially reducing efficacy.
You may also like to solve these questions
Choose an antihypertensive agent that is most likely to produce tachycardia, fluid retention and hirsutism?
- A. Captopril
- B. Guanethidine
- C. Minoxidil
- D. Prazosin
Correct Answer: C
Rationale: Minoxidil causes reflex tachycardia, fluid retention, and hirsutism.
Precautions that should be taken when prescribing controlled substances include:
- A. Faxing the prescription for a Schedule II drug directly to the pharmacy
- B. Using tamper-proof paper for all prescriptions written for controlled drugs
- C. Keeping any pre-signed prescription pads in a locked drawer in the clinic
- D. Using only numbers to indicate the amount of drug to be prescribed
Correct Answer: B
Rationale: Tamper-proof paper prevents fraud, a key precaution; faxing Schedule II has restrictions, and locking pads or numbers-only are less specific.
Patient education regarding the use of ciprofloxacin-hydrocortisone (Cipro HC otic) ear drops includes:
- A. Fill the canal with the drops with each dose
- B. Some redness and itching around the ear canal is normal
- C. Warm the bottle of ear drops in his or her hand before administering
- D. Cipro HC otic may cause ototoxicity
Correct Answer: C
Rationale: Warming Cipro HC improves comfort; filling or ototoxicity aren't standard advice.
A patient has been using sleeping pills every night for the past several months. Now admitted to the hospital, he is prescribed his usual dose of sleeping pill. After administration, the patient continues to be restless and is wide awake. The nurse notifies the health care provider, who prescribes an increased dose. After receiving the new dose, the patient falls asleep. The nurse interprets this as which of the following?
- A. Drug idiosyncrasy
- B. Cumulative drug effect
- C. Drug tolerance
- D. Toxic reactions
Correct Answer: C
Rationale: The patient has developed drug tolerance and has to be administered an increased dosage of the drug to achieve the desired effect. Cumulative drug effect occurs when the body is unable to metabolize and excrete one (normal) dose of a drug before the next dose is given. Drug idiosyncrasy is a term used to describe any unusual or abnormal reaction to a drug. Toxic reactions are caused when blood concentration levels exceed the therapeutic levels of a drug.
When writing a prescription for warfarin it is common to write ____ on the prescription.
- A. OK to substitute for generic
- B. The brand name of warfarin and Do Not Substitute
- C. PRN refills
- D. Refills for 1 year
Correct Answer: B
Rationale: Brand-specific warfarin ensures consistent potency; generics vary slightly, and PRN or yearly refills are impractical.