Nokea
Which statement is true about over-the-counter (OTC) drugs?
- A. They are not listed in the USP NF
- B. A prescription from a healthcare provider is needed
- C. They are sold without a prescription
- D. They are known only by their brand names
Correct Answer: C
Rationale: OTC medications do not require a prescription and are sold freely, listed in the USP NF, and known by both generic and brand names.
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Which route of drug administration is most likely to lead to first pass effect?
- A. Sublingual
- B. Oral
- C. Intravenous
- D. Intramuscular
Correct Answer: B
Rationale: Oral administration subjects drugs to the first-pass effect, where they are metabolized by the liver via the portal vein before reaching systemic circulation, reducing bioavailability.
GLP-1 agonists:
- A. Directly bind to a receptor in the pancreatic beta cell
- B. Have been approved for monotherapy
- C. Speed gastric emptying to decrease appetite
- D. Can be given orally once daily
Correct Answer: A
Rationale: GLP-1 agonists bind beta-cell receptors to enhance insulin release; they're not monotherapy-approved or oral .
A nurse is preparing a prescribed dose of rabeprazole for a client with gastric ulcers. The nursing drug guide does not list treatment of gastric ulcers among the recognized indications for this drug. What should the nurse do?
- A. Administer the drug as ordered
- B. Clarify with the prescriber concerning the ordered drug
- C. Document this potential error in the client's health record
- D. Ask the client whether he or she has taken this drug before
Correct Answer: B
Rationale: Rabeprazole is typically for GERD, not gastric ulcers per standard indications; clarifying with the prescriber ensures safety and appropriateness.
A nurse is instructing a client who has a new prescription for Timolol how to insert eye drops. The nurse should instruct the client to press on which of the following areas to prevent systemic absorption of the medication?
- A. Bony orbit
- B. Nasolacrimal duct
- C. Conjunctival sac
- D. Outer canthus
Correct Answer: B
Rationale: Pressing the nasolacrimal duct prevents systemic absorption by blocking drainage into the nasal cavity.
Glucocorticoids enhance:
- A. Inhibition of phospholipase A2 in leukocytes with stimulation of annexin synthesis
- B. Decrease of thrombocyte activating factor via inhibition of 5 lipooxigenase
- C. Inhibition of leukotriene synthesis and decrease of lyso-glycerilphosphorilcholine production
- D. inhibition of prostaglandin synthesis via blocking 12 lypooxigenase
Correct Answer: A
Rationale: Glucocorticoids inhibit phospholipase A2, reducing inflammatory mediators by stimulating annexin (lipocortin) synthesis.