Nokea
Drugs bound to albumin are inactive.
- A. TRUE
- B. FALSE
Correct Answer: A
Rationale: True; drugs bound to albumin are inactive as only the free (unbound) fraction can interact with receptors or be metabolized/excreted.
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The student nurse asks the instructor why a patient with a central nervous system infection is receiving antibiotics that will not cross the blood-brain barrier. What is the instructor's most correct response?
- A. A severe infection alters the blood-brain barrier to allow the drug to cross.
- B. A medication that is water soluble is more likely to cross the blood-brain barrier.
- C. Antibiotics are the exception to the blood-brain barrier and cross easily.
- D. An infection that spreads outside the central nervous system helps drugs cross the barrier.
Correct Answer: A
Rationale: Effective antibiotic treatment can occur only when the infection is severe enough to alter the blood-brain barrier and allow antibiotics to cross. Lipid-soluble, not water-soluble, medications cross the blood-brain barrier more easily and most antibiotics are lipid soluble, so they are not the exception. No matter where the infection originates, drugs must cross the blood-brain barrier to treat central nervous system infections.
Which cephalosporin generation is effective against methicillin-resistant Staphylococcus aureus (MRSA)?
- A. First generation
- B. Second generation
- C. Third generation
- D. Fifth generation
Correct Answer: D
Rationale: Fifth-generation cephalosporins, like ceftaroline, are effective against MRSA, unlike earlier generations.
A community health nurse visits a client at home. Prednisone 10 mg orally daily has been prescribed for the client and the nurse reinforces teaching for the client about the medication. Which statement, if made by the client, indicates that further teaching is necessary?
- A. I can take aspirin or my antihistamine if I need it.'
- B. I need to take the medication every day at the same time.'
- C. I need to avoid coffee, tea, cola, and chocolate in my diet.'
- D. If I gain more than 5 pounds a week, I will call my doctor.'
Correct Answer: A
Rationale: Aspirin and other over-the-counter medications should not be taken unless the client consults with the health care provider (HCP). The client needs to take the medication at the same time every day and should be instructed not to stop the medication. A slight weight gain as a result of an improved appetite is expected, but after the dosage is stabilized, a weight gain of 5 lb or more weekly should be reported to the HCP. Caffeine-containing foods and fluids need to be avoided because they may contribute to steroid-ulcer development.
Which of the following glucocorticosteroids are used for cerebral oedema:
- A. Triamcinolon
- B. Prednisolon
- C. Prednison
- D. Dexamethasone
Correct Answer: D
Rationale: Dexamethasone is preferred for cerebral edema due to its potent anti-inflammatory effects and minimal mineralocorticoid activity.
Which of the following is the indication for glucocorticoid prescribing?
- A. Cataract
- B. Prevention of respiratory distress
- C. Hypofunction of thyroid gland
- D. Hypocalcemia
Correct Answer: B
Rationale: Glucocorticoids are indicated to prevent respiratory distress, such as in preterm infants for lung maturation.