Nokea
Effects of glucagon are:
- A. Positive inotropic and chronotropic effects
- B. Negative inotropic and chronotropic effects
- C. Inhibition of Gs protein and decrease of CAMP
- D. Activation of Gq and accumulation of Inositol triphosphate
Correct Answer: A
Rationale: Glucagon has positive inotropic and chronotropic effects on the heart, increasing contractility and rate.
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As a clinical consultant for the Breathright drug research firm, you are given the task of using an in vitro assay to screen ten thousand drug analogs to find the most potent beta-2 receptor agonist. When analysing your data, the biomarker that you should screen for is:
- A. E max
- B. Emax
- C. EC50
- D. Half life
Correct Answer: C
Rationale: Potency is measured by EC50 (dose producing 50% of max effect); lower EC50 indicates higher potency.
It is often necessary to obtain baseline data prior to initiating many forms of drug therapy. These baseline data include what? (Select all that apply.)
- A. Education level
- B. Allergies
- C. wealth
- D. Number of members in family
Correct Answer: B
Rationale: Allergies and drug use directly impact therapy safety and efficacy; education and family size are less relevant.
A nursing student is preparing to administer a prescribed drug to a patient. The student reviews information about the drug and its actions. Which of the following would be the best choice for obtaining this information?
- A. Nursing instructor
- B. Nurse assigned to the patient
- C. Clinical drug reference
- D. Prescribing health care provider
Correct Answer: C
Rationale: Although the nursing student can ask the nursing instructor, the nurse assigned to the patient, and the prescribing health care provider for information about the drug, the best choices for drug information would include an appropriate drug reference and the clinical pharmacist.
A client who has been newly diagnosed with diabetes mellitus has been stabilized with daily insulin injections. Which information should the nurse teach when carrying out plans for discharge?
- A. Keep insulin vials refrigerated at all times.
- B. Rotate the insulin injections systematically.
- C. Increase the amount of insulin before unusual exercise.
- D. Monitor the urine acetone level to determine the insulin dosage.
Correct Answer: B
Rationale: Insulin dosages should not be adjusted or increased before unusual exercise. If acetone is found in the urine, it may possibly indicate the need for additional insulin. To minimize the discomfort associated with insulin injections, the insulin should be administered at room temperature. Injection sites should be systematically rotated from one area to another. The client should be instructed to give injections in one area, about 1 inch apart, until the whole area has been used and then to change to another site. This prevents dramatic changes in daily insulin absorption.
The nurse is counseling a patient who wants to stop smoking. Which statement by the nurse is correct?
- A. Bupropion (Zyban) is effective and does not have serious adverse effects
- B. Nicotine replacement therapies are effective and eliminate the need for behavioral therapy
- C. Varenicline (Chantix) may be used short-term for 1 to 2 months
- D. You may experience headaches and increased appetite for several months after stopping smoking
Correct Answer: D
Rationale: Headaches and appetite increase are common nicotine withdrawal symptoms; bupropion has side effects, and varenicline is longer-term. Headaches and increased appetite are common during nicotine withdrawal and may last for several months.