Nokea
Administration of sulfonamide may intensify the action of tolbutamide, through:
- A. Activation of the islets of pancreas
- B. Direct action on the utilization of glucose
- C. Synergistic action
- D. Competing with tolbutamide in plasma protein binding
Correct Answer: D
Rationale: Sulfonamides displace tolbutamide from plasma proteins, increasing free drug levels and enhancing its hypoglycemic effect.
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Which of the following would be the best source of drug information for a nurse?
- A. Drug Facts and Comparisons book
- B. A nurse's drug guide
- C. A drug package insert
- D. The Physician's Drug Reference (PDR)
Correct Answer: B
Rationale: The most user-friendly drug source for a nurse is a nurse's drug guidebook. A guide provides nursing implications and patient teaching points that are most useful to nurses. The Drug Facts and Comparisons book provides a wide range of drug information but is hard to manipulate and is very expensive. A package insert contains all of the chemical and drug company research information about a drug, however, the information can be difficult to understand and the print is very small. The PDR is heavily cross-referenced and difficult to use.
Tick the second messenger of G-protein-coupled (metabotropic) receptor:
- A. Adenylyl cyclase
- B. Sodium ions
- C. Phospholipase C
- D. cAMP
Correct Answer: D
Rationale: cAMP is a classic second messenger generated by G-protein-coupled receptors via adenylyl cyclase.
Phil is starting treatment with febuxostat (Uloric). Education of patients starting febuxostat includes:
- A. Gout may worsen with therapy
- B. Febuxostat may cause severe diarrhea
- C. He should consume a high-calcium diet
- D. He will need frequent CBC monitoring
Correct Answer: A
Rationale: Febuxostat can initially worsen gout as uric acid mobilizes; diarrhea or calcium aren't emphasized.
Which hormones are produces by pancreas?
- A. Calcitirne
- B. Corticotropin
- C. Insuline
- D. Dopamine
Correct Answer: C
Rationale: Insulin and glucagon are produced by the pancreas, regulating blood glucose levels; the others are not pancreatic hormones.
When melatonin is used to induce sleep, the recommendation is that the patient:
- A. Take 10 mg 30 minutes before bed nightly
- B. Take 1 to 5 mg 30 minutes before bed nightly
- C. Not take melatonin more than three nights a week
- D. Combine melatonin with zolpidem (Ambien) for the greatest impact on sleep
Correct Answer: B
Rationale: 1-5 mg of melatonin 30 minutes before bed is the recommended dose for sleep induction.