Nokea
Etiological factors for the infectious diseases are often microorganisms with various ultrastructure. Which of the following microorganism groups relates to the eukaryotes?
- A. Protozoa
- B. Viruses
- C. Viroids
- D. Prions
Correct Answer: A
Rationale: The correct answer is A: Protozoa. Protozoa are eukaryotic microorganisms, meaning they have a true nucleus and membrane-bound organelles. This relates to the question as eukaryotes are organisms with complex cells containing these features. Viruses (B) are non-living entities that require a host cell to replicate, lacking cellular structures. Viroids (C) are smaller than viruses and consist of only RNA, lacking a protein coat. Prions (D) are misfolded proteins causing diseases but are not considered microorganisms nor do they have cellular structure. Thus, protozoa are the only eukaryotic microorganism group among the options.
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One of the basic principles of chemotherapy is:
- A. Selective toxicity
- B. Accumulation in the macroorganism
- C. Causing allergies to the macroorganism
- D. None of the above
Correct Answer: A
Rationale: The correct answer is A: Selective toxicity. Chemotherapy aims to target cancer cells while minimizing harm to healthy cells, known as selective toxicity. This principle is crucial to effectively treat cancer without causing excessive damage to the patient's body. Accumulation in the macroorganism (B) and causing allergies (C) are not fundamental principles of chemotherapy and can lead to harmful side effects. Therefore, the correct answer is A as it aligns with the core objective of chemotherapy.
The main function of bacterial ribosomes is:
- A. DNA replication
- B. protein synthesis
- C. cell wall synthesis
- D. RNA splicing
Correct Answer: B
Rationale: The correct answer is B: protein synthesis. Bacterial ribosomes are responsible for translating messenger RNA into proteins through a process called translation. Ribosomes are composed of both protein and RNA molecules and facilitate the binding of transfer RNA to the messenger RNA to assemble the amino acids in the correct order to form a protein. DNA replication (A) is carried out by enzymes such as DNA polymerase, not ribosomes. Cell wall synthesis (C) is a process involving enzymes that build the structure of the cell wall in bacteria. RNA splicing (D) is a eukaryotic process that involves removing introns from pre-mRNA molecules, which is not a function of bacterial ribosomes.
The Staphylococcus aureus toxin, which can cause scalded skin syndrome (SSS), is:
- A. hemolysis
- B. enterotoxin
- C. leucocidin
- D. epidermolytic toxin
Correct Answer: D
Rationale: The correct answer is D: epidermolytic toxin. This toxin specifically targets the epidermis, leading to exfoliation seen in scalded skin syndrome (SSS). Hemolysis (A) refers to the destruction of red blood cells, not relevant to SSS. Enterotoxins (B) cause food poisoning, not SSS. Leucocidins (C) target white blood cells, not pertinent to SSS. Therefore, the epidermolytic toxin (D) is the correct choice for causing SSS.
A 40-year-old patient presents with abdominal pain, frequent loose stools with mucus and blood. Stool analysis revealed vegetative forms of some protozoa sized 30-40 microns, with short pseudopodia, containing large amounts of phagocytosed erythrocytes. What protozoan disease does the patient have?
- A. Amebiasis
- B. Leishmaniasis
- C. Trichomoniasis
- D. Giardiasis
Correct Answer: A
Rationale: The correct answer is Amebiasis. The patient's symptoms of abdominal pain, loose stools with mucus and blood, along with the presence of protozoa containing phagocytosed erythrocytes in stool analysis are indicative of Entamoeba histolytica infection. The size (30-40 microns) and pseudopodia characteristics match E. histolytica. Amebiasis commonly presents with dysentery, while Leishmaniasis (B) typically causes skin ulcers. Trichomoniasis (C) is a sexually transmitted infection, not associated with the described symptoms. Giardiasis (D) is characterized by foul-smelling diarrhea and steatorrhea, not bloody diarrhea as seen in this case.
Which of the following diseases is transmitted by the fecal–oral route?
- A. Ehrlichiosis
- B. Peptic ulcer
- C. Lyme disease
- D. Tularemia
Correct Answer: B
Rationale: The correct answer is B: Peptic ulcer. Peptic ulcers are commonly caused by Helicobacter pylori bacteria, which can be transmitted through the fecal-oral route. This means that the bacteria from infected feces can be ingested through contaminated food or water, leading to the development of peptic ulcers in the gastrointestinal tract.
Incorrect choices:
A: Ehrlichiosis - Ehrlichiosis is a tick-borne disease transmitted through the bite of an infected tick, not through the fecal-oral route.
C: Lyme disease - Lyme disease is also transmitted through the bite of an infected tick, specifically the black-legged tick.
D: Tularemia - Tularemia is a bacterial disease typically transmitted through insect bites, handling of infected animals, or ingestion of contaminated water, not through the fecal-oral route.