Nokea
Felicity has been prescribed colestipol to treat her hyperlipidemia. Unlike other anti-lipidemics, this drug:
- A. Blocks synthesis of cholesterol in the liver
- B. Exchanges chloride ions for negatively charged acids in the bowel
- C. Increases HDL levels the most among the classes
- D. Blocks the lipoprotein lipase pathway
Correct Answer: B
Rationale: Colestipol, a bile acid resin, binds bile acids in the bowel.
You may also like to solve these questions
The following are recognized effects of propranolol except
- A. Increases microcoronary blood flow
- B. Decrease in heart rate
- C. Decrease in cardiac output
- D. Reduction in ventricular systolic pressure
Correct Answer: A
Rationale: Propranolol reduces coronary flow; other effects are correct.
Selma, who is overweight, recently started taking topiramate for seizures and at her follow-up visit you note she has lost 3 kg. The appropriate action would be:
- A. Tell her to increase her caloric intake to counter the effects of the topiramate.
- B. Consult with a neurologist, as this is not a common adverse effect of topiramate.
- C. Decrease her dose of topiramate.
- D. Reassure her that this is a normal side effect of topiramate and continue to monitor her weight.
Correct Answer: D
Rationale: Weight loss is a common, beneficial side effect of topiramate.
NSAIDs combat fever by inhibiting which prostaglandin?
- A. Prostaglandin E2
- B. Prostaglandin I2
- C. Prostaglandin D2
- D. Prostaglandin F2
Correct Answer: A
Rationale: Prostaglandin E2 mediates fever in the hypothalamus; NSAIDs reduce fever by inhibiting its synthesis.
A patient wants to know about the possible interactions of the various drugs that he has been prescribed for an illness. The nurse explains that the drugs interact with each other and produce an effect that is greater than the sum of their separate actions. Which of the following reactions is the nurse informing about?
- A. Additive drug reaction
- B. Synergistic drug reaction
- C. Antagonistic drug reaction
- D. Toxic drug reaction
Correct Answer: B
Rationale: A synergistic drug reaction occurs when drugs interact with each other and produce a sum greater than the sum of their separate actions. An additive drug reaction occurs when the combined effect of two drugs is equal to the sum of each drug given alone. An antagonistic drug reaction occurs when one drug interferes with the action of another, causing neutralization or a decrease in the effect of one drug. Toxic drug reactions are caused when blood concentration levels exceed the therapeutic levels of a drug.
Which of the following drugs do not cross the placenta
- A. Dilantin
- B. Diazepam
- C. Acinocoumarin
- D. Heparin
Correct Answer: D
Rationale: Heparin does not cross the placenta due to its large size.