Nokea
Grapefruit juice contains furanocoumarins that have been found to:
- A. Alter absorption of drugs through competition for binding sites
- B. Inhibit CYP 3A4, leading to decreased first-pass metabolism of drugs
- C. Alter vitamin K metabolism, leading to prolonged bleeding
- D. Enhance absorption of calcium and vitamin D
Correct Answer: B
Rationale: Furanocoumarins in grapefruit juice inhibit CYP3A4, reducing first-pass metabolism and increasing drug levels (e.g., statins).
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A 15 year old girl experiences epileptic fits during her menstrual periods. Which ONE of the following drugs is best suited for the management of her condition?
- A. Ethosuximide
- B. Valproic acid
- C. Phenytoin
- D. Corticosteroids
Correct Answer: B
Rationale: Valproic acid is effective for catamenial epilepsy and tonic-clonic seizures.
A nurse is caring for a client who has a new prescription for Phenelzine for the treatment of depression. Which of the following indicates that the client has developed an adverse effect of this medication?
- A. Orthostatic hypotension
- B. Hearing loss
- C. Gastrointestinal bleeding
- D. Weight loss
Correct Answer: A
Rationale: Phenelzine, an MAOI, commonly causes orthostatic hypotension due to its effect on blood pressure regulation.
Which of the following medications has not hypoglycemic effect:
- A. Insulin
- B. Glucagon
- C. Metformin
- D. Glibenclamid
Correct Answer: B
Rationale: Glucagon raises blood glucose levels, unlike the others which lower it.
A nurse reviewing a client's health record notes a new prescription for Lisinopril 10 mg PO once every day. The nurse should identify this as which of the following types of prescription?
- A. Single
- B. Stat
- C. Routine
- D. Standing
Correct Answer: C
Rationale: A daily dose (once every day) indicates a routine prescription for ongoing treatment.
____ is / are prescribed to prevent swimmer's ear.
- A. Ciprofloxacin otic drops (Ciloxan)
- B. Isopropyl ear drops (EarSol)
- C. Colistin (Coly-Mycin S Otic)
- D. Gentamicin otic drops
Correct Answer: B
Rationale: Isopropyl alcohol dries the ear canal, preventing swimmer's ear; antibiotics treat, not prevent.