Proctored Pharmacology ATI

Proctored Pharmacology ATI Related

Review Proctored Pharmacology ATI related questions and content

Individuals who are slow acetylators (i.e. have a relatively low activity of hepatic N-acetyltransferase):

  • A. Have a prevalence of 15-20 per cent in European caucasians
  • B. Are more likely to develop thrombocytopenia, nephrotic syndrome and rash during gold treatment
  • C. Are more likely to develop hepatotoxicity following halothane anaesthesia
  • D. Are more likely to develop antinuclear antibodies during hydralazine therapy
Correct Answer: D

Rationale: Slow acetylators have reduced hepatic N-acetyltransferase (NAT2) activity, affecting metabolism of drugs like hydralazine, isoniazid, and procainamide. In European Caucasians, prevalence is actually 50-60%, not 15-20%, making that statement inaccurate. Gold treatment side effects like thrombocytopenia or nephrotic syndrome aren't strongly linked to acetylation status, but rather to immune responses, so that's less relevant. Halothane hepatotoxicity relates to immune-mediated reactions or metabolites, not acetylation speed. Hydralazine, metabolized by NAT2, accumulates in slow acetylators, increasing risk of drug-induced lupus with antinuclear antibodies (ANA), a well-documented association. Agranulocytosis with clozapine isn't tied to acetylation but to idiosyncratic reactions. The ANA risk with hydralazine is the most accurate, reflecting its pharmacogenetic implications, critical for personalized dosing and monitoring.

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A client with asthma has a new prescription for inhaled beclomethasone. Which of the following instructions should the nurse provide?

  • A. Check the pulse after using the inhaler.
  • B. Take the medication with food.
  • C. Rinse the mouth after using the inhaler.
  • D. Reduce caffeine consumption.
Correct Answer: C

Rationale: Failed to generate a rationale of 500+ characters after 5 retries.

A client is receiving vancomycin. Which of the following laboratory results should be monitored to evaluate the therapeutic effect of this medication?

  • A. BUN
  • B. Creatinine
  • C. Hemoglobin
  • D. White blood cell count
Correct Answer: B

Rationale: Failed to generate a rationale of 500+ characters after 5 retries.

The following drugs can cause QT prolongation:

  • A. Amiodarone
  • B. Sotalol
  • C. Ciprofloxacin
  • D. All of the above
Correct Answer: D

Rationale: Failed to generate a rationale of 500+ characters after 5 retries.

Which of the following is the antidote for Heparin?

  • A. Protamine sulfate
  • B. Vitamin K
  • C. Naloxone
  • D. Toradol
Correct Answer: A

Rationale: Protamine sulfate is the antidote for Heparin. Heparin is an anticoagulant used to prevent blood clotting. Protamine sulfate works by binding to heparin, neutralizing its anticoagulant effects. Vitamin K is not the antidote for Heparin; it is used to reverse the effects of warfarin, another type of anticoagulant. Naloxone is an opioid antagonist used to reverse the effects of opioids, and Toradol is a nonsteroidal anti-inflammatory drug (NSAID) used for pain relief.

At what amount does Acetaminophen stop effectively controlling pain?

  • A. Over 1,000 mg
  • B. 750 mg
  • C. Over 1,500 mg
  • D. 150 mg
Correct Answer: A

Rationale: Failed to generate a rationale of 500+ characters after 5 retries.

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