Nokea
Infants and young children are at higher risk of ADRs due to:
- A. Immature renal function in school-age children
- B. Lack of safety and efficacy studies in the pediatric population
- C. Children's skin being thicker than adults, it is less likely to absorb dosages of topical medication
- D. Infant boys having a higher proportion of muscle mass, leading to a higher volume of distribution
Correct Answer: B
Rationale: Lack of pediatric studies increases ADR risk due to unestablished safety/efficacy, unlike renal maturity , skin thickness (C, false), or muscle mass (D, false).
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Mutations in receptor tyrosine kinases would most likely be associated with :
- A. Neurologic diseases
- B. Endocrine diseases
- C. Cancers
- D. Metabolic abnormalities
Correct Answer: C
Rationale: Receptor tyrosine kinases are often linked to uncontrolled cell growth when mutated, commonly associated with cancers.
Which drug(s) would be considered to be in the category Schedule II? (Select all that apply.)
- A. Marijuana
- B. Morphine
- C. Amphetamines
- D. Fiorinal
Correct Answer: C
Rationale: Percodan and amphetamines are Schedule II drugs with high abuse potential. Marijuana is Schedule I, Fiorinal is Schedule III.
When comparing angiotensin-converting enzyme (ACE) and angiotensin II receptor blocker (ARB) medications, which of the following holds true?
- A. Both have major issues with a dry, irritating cough
- B. Both contribute to some retention of potassium
- C. ARBs have a stronger impact on hypertension control than ACE medications
- D. ARBs have stronger diabetes mellitus renal protection properties than ACE medications
Correct Answer: B
Rationale: Both ACEIs and ARBs cause potassium retention due to reduced aldosterone.
Long-acting beta-agonists (LTBAs) received a Black Box Warning from the U.S. Food and Drug Administration due to the:
- A. Risk of life-threatening dermatological reactions
- B. Increased incidence of cardiac events when LTBAs are used
- C. Increased risk of asthma-related deaths when LTBAs are used
- D. Risk for life-threatening alterations in electrolytes
Correct Answer: C
Rationale: The FDA Black Box Warning for LTBAs highlights increased asthma-related mortality risk, not dermatologic , cardiac , or electrolyte issues.
Sallie has been taking 10 mg per day of prednisone for the past 6 months. She should be assessed for:
- A. Gout
- B. Iron deficiency anemia
- C. Osteoporosis
- D. Renal dysfunction
Correct Answer: C
Rationale: Chronic prednisone increases osteoporosis risk via bone loss; gout or anemia are less direct.