Monitoring for a patient being prescribed iron for iron deficiency anemia includes:
- A. Reticulocyte count 1 week after therapy is started
- B. Complete blood count every 2 weeks throughout therapy
- C. Hemoglobin level at 1 week of therapy
- D. INR weekly throughout therapy
Correct Answer: A
Rationale: Reticulocyte count at 1 week assesses iron therapy response; CBC or hemoglobin checks are later, and INR is irrelevant.
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Which of the following is a stimulative mechanism of insulin secretion:
- A. Hyperglicemia and decrease of intracellular ATP
- B. Increase of intracellular ATP and opening of ATP-depended K+ channels
- C. Increase of intracellular ATP and closure of ATP-depended K+ channels
- D. Closure of potential depended Ca+2 channels
Correct Answer: C
Rationale: Insulin secretion is stimulated by increased ATP closing K+ channels, depolarizing beta cells and opening Ca2+ channels.
The major factor in terminating the action of ethanol is
- A. Biotransformation
- B. Excretion through lungs
- C. Excretion unchanged in urine
- D. Excretion in feces
Correct Answer: A
Rationale: Ethanol is primarily metabolized by the liver (biotransformation) via alcohol dehydrogenase.
Which of the following drugs should be used only when clearly needed in pregnant and breastfeeding women?
- A. Memantine
- B. Pyridostigmine
- C. Galantamine
- D. Rivastigmine
Correct Answer: B
Rationale: Pyridostigmine's safety in pregnancy/breastfeeding is less established, requiring caution.
Which drug(s) would be considered to be in the category Schedule II? (Select all that apply.)
- A. Marijuana
- B. Morphine
- C. Amphetamines
- D. Fiorinal
Correct Answer: C
Rationale: Percodan and amphetamines are Schedule II drugs with high abuse potential. Marijuana is Schedule I, Fiorinal is Schedule III.
Infants and young children are at higher risk of ADRs due to:
- A. Immature renal function in school-age children
- B. Lack of safety and efficacy studies in the pediatric population
- C. Children's skin being thicker than adults, it is less likely to absorb dosages of topical medication
- D. Infant boys having a higher proportion of muscle mass, leading to a higher volume of distribution
Correct Answer: B
Rationale: Lack of pediatric studies increases ADR risk due to unestablished safety/efficacy, unlike renal maturity , skin thickness (C, false), or muscle mass (D, false).
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