Nokea
Mechanisms of transmembrane signaling are the following EXCEPT:
- A. Transmembrane receptors that bind and stimulate a protein tyrosine kinase
- B. Gene replacement by the introduction of a therapeutic gene to correct a genetic effect
- C. Ligand-gated ion channels that can be induced to open or close by binding a ligand
- D. Transmembrane receptor protein that stimulates a GTP-binding signal transducer protein (G-protein) which in turn generates an intracellular second messenger
Correct Answer: B
Rationale: Gene replacement is a therapeutic strategy, not a signaling mechanism.
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The patient asks the nurse why generic drugs would be used and voices concerns that only the brand name product will be safe. What is the nurses best response?
- A. Generic drugs are often less expensive.
- B. Some quality control problems have been found with generic drugs.
- C. Most generic drugs are very safe and can be cost effective as well.
- D. Although initial cost is higher for a brand name it may cost less in the long run.
Correct Answer: C
Rationale: Most generic medications are completely safe and may be identical to the brand name drug except generic medications are often less expensive, but this does not address the patients concern about safety. Although some quality control issues have occurred in the past, this does not address the patients concerns regarding safety or explain why generic drugs are prescribed and used. Although some doctors believe initial cost is higher but will cost less over time, this response also does not address the patients concerns.
Drug which crosses the placental barrier is:
- A. Phenytoin
- B. Diazepam
- C. Corticosterioids
- D. All of the above
Correct Answer: D
Rationale: All listed drugs cross the placenta, affecting the fetus.
Common side effect of isoniazide:
- A. Hepatitis
- B. Ototoxicity
- C. Visual toxicity
- D. Hepatitis
Correct Answer: A
Rationale: Isoniazid (likely misspelled as Isoniazide) commonly causes hepatitis as a side effect due to its hepatotoxic potential, requiring liver function monitoring. Note: Option D repeats 'Hepatitis,' but A is intended.
A patient is prescribed lidocaine for ventricular arrhythmias. Which side effect should the nurse monitor for?
- A. Hypotension
- B. Nausea
- C. Seizures
- D. Bradycardia
Correct Answer: C
Rationale: Lidocaine, a Class IB antiarrhythmic, can cause CNS side effects like seizures at high doses, a key monitoring point.
A nurse is preparing to administer clindamycin 200 mg by intermittent IV bolus. The amount available is clindamycin injection 200 mg in 100 mL 0.9% sodium chloride (0.9% NaCl) to infuse over 30 min. The nurse should set the IV pump to deliver how many mL/hr? (Round the answer to the nearest whole number. Do not use a trailing zero.)
- A. 200
- B. 180
- C. 250
- D. 500
Correct Answer: A
Rationale: Calculation: (100 mL / 30 min) 60 min/hr = 200 mL/hr, matching the provided answer.